Back to Search
Start Over
Macrophage migrating inhibitory factor expression is associated with Trypanosoma brucei gambiense infection and is controlled by trans-acting expression quantitative trait loci in the Guinean population
- Source :
- Infection, Genetics and Evolution, Infection, Genetics and Evolution, 2019, 71, pp.108-115. ⟨10.1016/j.meegid.2019.03.021⟩, INFECTION GENETICS AND EVOLUTION, Infection, Genetics and Evolution, Elsevier, 2019, 71, pp.108-115. ⟨10.1016/j.meegid.2019.03.021⟩
- Publication Year :
- 2019
- Publisher :
- HAL CCSD, 2019.
-
Abstract
- Infection by Trypanosoma brucei gambiense is characterized by a wide array of clinical outcomes, ranging from asymptomatic to acute disease and even spontaneous cure. In this study, we investigated the association between macrophage migrating inhibitory factor (MIF), an important pro-inflammatory cytokine that plays a central role in both innate and acquired immunity, and disease outcome during T. b. gambiense infection. A comparative expression analysis of patients, individuals with latent infection and controls found that MIF had significantly higher expression in patients (n = 141; 1.25 ± 0.07; p
- Subjects :
- Adult
Male
0301 basic medicine
Microbiology (medical)
Chemokine
Adolescent
Trypanosoma brucei gambiense
medicine.medical_treatment
[SDV]Life Sciences [q-bio]
Quantitative Trait Loci
030106 microbiology
Population
Microbiology
Young Adult
03 medical and health sciences
Genotype
Genetics
medicine
Humans
CXCL13
Child
education
Macrophage Migration-Inhibitory Factors
Molecular Biology
Gene
Ecology, Evolution, Behavior and Systematics
Aged
Aged, 80 and over
education.field_of_study
biology
Gene Expression Profiling
Middle Aged
Acquired immune system
Chemokine CXCL13
3. Good health
Trypanosomiasis, African
030104 developmental biology
Infectious Diseases
Cytokine
Gene Expression Regulation
Child, Preschool
Immunology
Expression quantitative trait loci
biology.protein
Female
Guinea
Subjects
Details
- Language :
- English
- ISSN :
- 15671348 and 15677257
- Database :
- OpenAIRE
- Journal :
- Infection, Genetics and Evolution, Infection, Genetics and Evolution, 2019, 71, pp.108-115. ⟨10.1016/j.meegid.2019.03.021⟩, INFECTION GENETICS AND EVOLUTION, Infection, Genetics and Evolution, Elsevier, 2019, 71, pp.108-115. ⟨10.1016/j.meegid.2019.03.021⟩
- Accession number :
- edsair.doi.dedup.....9606794d3c88d9930456c3c7af366b6d