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Hematopoietic stem cell transplantation with latently infected donors does not transmit virus to immunocompromised recipients in the murine model of cytomegalovirus infection
- Source :
- Medical Microbiology and Immunology. 197:251-259
- Publication Year :
- 2008
- Publisher :
- Springer Science and Business Media LLC, 2008.
-
Abstract
- Hematopoietic stem cell transplantation (HSCT) bears a risk of reactivating latent cytomegalovirus (CMV) in either the transplanted hematopoietic donor cells or in parenchymal and stromal tissue cells of the immunocompromised recipient, or in both. While reactivated human CMV in recipients of organ transplantations is frequently the virus variant of the donor, this is not usually the case in HSCT recipients. Here we have used experimental sex-mismatched HSCT in the BALB/c mouse model to test if latent murine CMV from CMV-immune donors is transmitted with bone marrow cells to naive immunocompromised recipients.
- Subjects :
- Male
Microbiology (medical)
Stromal cell
medicine.medical_treatment
Immunology
Congenital cytomegalovirus infection
Cytomegalovirus
Hematopoietic stem cell transplantation
medicine.disease_cause
Herpesviridae
Immunocompromised Host
Mice
Betaherpesvirinae
medicine
Animals
Immunology and Allergy
Mice, Inbred BALB C
biology
Hematopoietic Stem Cell Transplantation
virus diseases
General Medicine
biology.organism_classification
medicine.disease
Virology
Tissue Donors
Virus Latency
Transplantation
surgical procedures, operative
medicine.anatomical_structure
Cytomegalovirus Infections
Female
Bone marrow
Stem cell
Subjects
Details
- ISSN :
- 14321831 and 03008584
- Volume :
- 197
- Database :
- OpenAIRE
- Journal :
- Medical Microbiology and Immunology
- Accession number :
- edsair.doi.dedup.....95ff07f7ea1547377dc6e4413765c3ae