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Impact of Sleeve Gastrectomy on Weight Loss, Glucose Homeostasis, and Comorbidities in Severely Obese Type 2 Diabetic Subjects

Authors :
Giuliana Vitolo
Luigi Angrisani
G. Saldalamacchia
Roberta Lupoli
Brunella Capaldo
Gabriella Nosso
Pier Paolo Cutolo
M. Cotugno
Nosso, Gabriella
Angrisani, Luigi
Saldalamacchia, Gennaro
Cutolo, Pp
Cotugno, Mariella
Lupoli, Roberta
Vitolo, G
Capaldo, Brunella
Source :
Journal of Obesity, Vol 2011 (2011), Journal of Obesity
Publication Year :
2011
Publisher :
Hindawi Limited, 2011.

Abstract

This study was undertaken to assess medium-term effects of laparoscopic sleeve gastrectomy (LSG) on body weight and glucose homeostasis in severely obese type 2 diabetic (T2DM) subjects. Twenty-five obese T2DM subjects (10 M/15 F, age45±9years, BMI48±8 kg/m2, M ± SD) underwent evaluation of anthropometric/clinical parameters and glucose homeostasis before, 3 and 9–15 months after LSG. Mean BMI decreased from48±8 kg/m2to40±9 kg/m2(P<.001) at 3 months and34±6 kg/m2(P<.001) at 9–15 months after surgery. Remission of T2DM (fasting plasma glucose < 126 mg/dL andHbA1c<6.5% in the absence of hypoglycemic treatment) occurred in all patients but one. There was a remarkable reduction in the percentage of patients requiring antihypertensive and hypolipidemic drugs. Our study shows that LSG is effective in producing a significant and sustained weight loss and improving glucose homeostasis in severely obese T2DM patients.

Details

Language :
English
ISSN :
20900716 and 20900708
Volume :
2011
Database :
OpenAIRE
Journal :
Journal of Obesity
Accession number :
edsair.doi.dedup.....95e9ee42f702f9250d6188538ad38bf6