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Impact of Sleeve Gastrectomy on Weight Loss, Glucose Homeostasis, and Comorbidities in Severely Obese Type 2 Diabetic Subjects
- Source :
- Journal of Obesity, Vol 2011 (2011), Journal of Obesity
- Publication Year :
- 2011
- Publisher :
- Hindawi Limited, 2011.
-
Abstract
- This study was undertaken to assess medium-term effects of laparoscopic sleeve gastrectomy (LSG) on body weight and glucose homeostasis in severely obese type 2 diabetic (T2DM) subjects. Twenty-five obese T2DM subjects (10 M/15 F, age45±9years, BMI48±8 kg/m2, M ± SD) underwent evaluation of anthropometric/clinical parameters and glucose homeostasis before, 3 and 9–15 months after LSG. Mean BMI decreased from48±8 kg/m2to40±9 kg/m2(P<.001) at 3 months and34±6 kg/m2(P<.001) at 9–15 months after surgery. Remission of T2DM (fasting plasma glucose < 126 mg/dL andHbA1c<6.5% in the absence of hypoglycemic treatment) occurred in all patients but one. There was a remarkable reduction in the percentage of patients requiring antihypertensive and hypolipidemic drugs. Our study shows that LSG is effective in producing a significant and sustained weight loss and improving glucose homeostasis in severely obese T2DM patients.
- Subjects :
- Laparoscopic sleeve gastrectomy
medicine.medical_specialty
Plasma glucose
Sleeve gastrectomy
type 2 diabete
lcsh:Internal medicine
Article Subject
business.industry
Endocrinology, Diabetes and Metabolism
medicine.medical_treatment
glucose metabolism
Anthropometry
Body weight
Gastroenterology
Surgery
Weight loss
Internal medicine
Clinical Study
Medicine
Glucose homeostasis
medicine.symptom
business
lcsh:RC31-1245
sleeve gastrectomy
Hypolipidemic Drugs
Subjects
Details
- Language :
- English
- ISSN :
- 20900716 and 20900708
- Volume :
- 2011
- Database :
- OpenAIRE
- Journal :
- Journal of Obesity
- Accession number :
- edsair.doi.dedup.....95e9ee42f702f9250d6188538ad38bf6