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Hypoxic Signaling During Tissue Repair and Regenerative Medicine
- Source :
- International Journal of Molecular Sciences, Nauta, T, van Hinsbergh, V W M & Koolwijk, P 2014, ' Hypoxic Signaling During Tissue Repair and Regenerative Medicine ', International Journal of Molecular Sciences, vol. 15, no. 11, pp. 19791-19815 . https://doi.org/10.3390/ijms151119791, International Journal of Molecular Sciences, Vol 15, Iss 11, Pp 19791-19815 (2014), International Journal of Molecular Sciences, 15(11), 19791-19815. Multidisciplinary Digital Publishing Institute (MDPI)
- Publication Year :
- 2014
-
Abstract
- In patients with chronic wounds, autologous tissue repair is often not sufficient to heal the wound. These patients might benefit from regenerative medicine or the implantation of a tissue-engineered scaffold. Both wound healing and tissue engineering is dependent on the formation of a microvascular network. This process is highly regulated by hypoxia and the transcription factors hypoxia-inducible factors-1α (HIF-1α) and -2α (HIF-2α). Even though much is known about the function of HIF-1α in wound healing, knowledge about the function of HIF-2α in wound healing is lacking. This review focuses on the function of HIF-1α and HIF-2α in microvascular network formation, wound healing, and therapy strategies.
- Subjects :
- medicine.medical_specialty
Scaffold
Angiogenesis
HIF-1α
Neovascularization, Physiologic
Review
Biology
Bioinformatics
Regenerative Medicine
Regenerative medicine
Catalysis
Hypoxia-Inducible Factor-Proline Dioxygenases
Inorganic Chemistry
lcsh:Chemistry
angiogenesis
Tissue engineering
medicine
Basic Helix-Loop-Helix Transcription Factors
Humans
Physical and Theoretical Chemistry
Molecular Biology
Transcription factor
lcsh:QH301-705.5
Spectroscopy
Wound Healing
integumentary system
Tissue Engineering
hypoxia
Organic Chemistry
HIF-2α
General Medicine
Tissue repair
Hypoxia (medical)
Computer Science Applications
Surgery
lcsh:Biology (General)
lcsh:QD1-999
medicine.symptom
Wound healing
Signal Transduction
Subjects
Details
- ISSN :
- 14220067
- Volume :
- 15
- Issue :
- 11
- Database :
- OpenAIRE
- Journal :
- International Journal of Molecular Sciences
- Accession number :
- edsair.doi.dedup.....95ddeb98990d283d4237d944600a7b59