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The myositis clinical phenotype associated with anti-Zo autoantibodies: a case series of nine UK patients
- Source :
- RHEUMATOLOGY, Rheumatology (Oxford, England), Tansley, S L, Betteridge, Z, Lu, H, Davies, E, Rothwell, S, New, P P, Chinoy, H, Gordon, P, Gunawardena, H, Lloyd, M, Stratton, R, Cooper, R & McHugh, N J 2019, ' The myositis clinical phenotype associated with anti-Zo autoantibodies: a case series of nine UK patients ', Rheumatology (Oxford) . https://doi.org/10.1093/rheumatology/kez504
- Publication Year :
- 2020
-
Abstract
- Objectives It has been over 10 years since the first report of autoantibodies directed against phenylalanyl tRNA synthetase (anti-Zo) in a patient with features of the anti-synthetase syndrome. In that time no further cases have been published. Here we aim to characterize more fully the clinical phenotype of anti-Zo–associated myositis by describing the clinical features of nine patients. Methods Anti-Zo was identified by protein-immunoprecipitation in patients referred for extended spectrum myositis autoantibody testing at our laboratory. Results were confirmed by immunodepletion using a reference serum. Medical records were retrospectively reviewed to provide detailed information of the associated clinical phenotype for all identified patients. Where possible, HLA genotype was imputed using Illumina protocols. Results Nine patients with anti-Zo were identified. The median age at disease onset was 51 years, and six patients were female. Seven patients had evidence of inflammatory muscle disease, seven of interstitial lung disease and six of arthritis. The reported pattern of interstitial lung disease varied with usual interstitial pneumonia, non-specific interstitial pneumonia and organizing pneumonia all described. Other features of the anti-synthetase syndrome such as RP and mechanics hands were common. HLA data was available for three patients, all of whom had at least one copy of the HLA 8.1 ancestral haplotype. Conclusion Patients with anti-Zo presenting with features of the anti-synthetase syndrome and interstitial lung disease is a common finding. Like other myositis autoantibodies, there is likely to be a genetic association with the HLA 8.1 ancestral haplotype.
- Subjects :
- Adult
Male
0301 basic medicine
medicine.medical_specialty
myositis and muscle disease
Arthritis
Human leukocyte antigen
autoantigens and autoantibodies
03 medical and health sciences
0302 clinical medicine
Rheumatology
Usual interstitial pneumonia
Internal medicine
medicine
Humans
Pharmacology (medical)
Age of Onset
Myositis
Aged
Autoantibodies
Retrospective Studies
Genetic association
030203 arthritis & rheumatology
business.industry
Haplotype
Interstitial lung disease
Autoantibody
biomarkers
Clinical Science
Middle Aged
respiratory
medicine.disease
United Kingdom
Phenotype
030104 developmental biology
Female
Phenylalanine-tRNA Ligase
business
Subjects
Details
- Language :
- English
- Database :
- OpenAIRE
- Journal :
- RHEUMATOLOGY, Rheumatology (Oxford, England), Tansley, S L, Betteridge, Z, Lu, H, Davies, E, Rothwell, S, New, P P, Chinoy, H, Gordon, P, Gunawardena, H, Lloyd, M, Stratton, R, Cooper, R & McHugh, N J 2019, ' The myositis clinical phenotype associated with anti-Zo autoantibodies: a case series of nine UK patients ', Rheumatology (Oxford) . https://doi.org/10.1093/rheumatology/kez504
- Accession number :
- edsair.doi.dedup.....95d4df43ab6c6f2eb21b0250702059df