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In silico and in vitro antioxidant and cytotoxicity evaluation of oxygenated xanthone derivatives
- Source :
- Arabian Journal of Chemistry, Vol 13, Iss 1, Pp 17-26 (2020)
- Publication Year :
- 2020
- Publisher :
- Elsevier BV, 2020.
-
Abstract
- Many natural products play important roles as antioxidants and represent useful scaffolds for the development of new agents. Particularly, polyphenols in which oxygenated xanthones can be included have proven their efficacy as antioxidants for several applications. To better understand the antioxidant potential of oxygenated xanthones, a library of twenty mono and di-oxygenated xanthones was investigated. The antioxidant properties were evaluated by their 2,2-diphenyl-1-picrylhydrazyl (DPPH) and peroxyl radical scavenging effect as well as their inhibitory effect on the prooxidant enzyme myeloperoxidase (MPO). A quantitative structure-activity relationship (QSAR) model predicted the maximal atomic partial charge (Qmax) as the descriptor being implied in the antioxidant activity of the referred xanthones. From the antioxidant screening, emerged the hit compound, 1,2-dihydroxyxanthone (10), that was further characterized for its chelating properties and its effect on a human keratinocyte cell line. Taken together, the results suggest the possible effectiveness of xanthone derivatives as antioxidants with potential for topical administration. Keywords: Antioxidant activity, Myeloperoxidase, Scavenging effect, Structure-activity relationships, Xanthones
- Subjects :
- Quantitative structure–activity relationship
Antioxidant
Chemistry(all)
DPPH
General Chemical Engineering
medicine.medical_treatment
02 engineering and technology
010402 general chemistry
01 natural sciences
lcsh:Chemistry
chemistry.chemical_compound
medicine
Chelation
Cytotoxicity
chemistry.chemical_classification
biology
Chemistry
General Chemistry
021001 nanoscience & nanotechnology
0104 chemical sciences
Enzyme
lcsh:QD1-999
Biochemistry
Polyphenol
Myeloperoxidase
Chemical Engineering(all)
biology.protein
0210 nano-technology
Subjects
Details
- ISSN :
- 18785352
- Volume :
- 13
- Database :
- OpenAIRE
- Journal :
- Arabian Journal of Chemistry
- Accession number :
- edsair.doi.dedup.....95d4889dbcd233819263e0b2962e1070