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Adjunctive brivaracetam for patients with refractory partial seizures: A meta-analysis of randomized placebo-controlled trials
- Source :
- Epilepsy research. 114
- Publication Year :
- 2015
-
Abstract
- To evaluate the clinical efficacy and safety of the newer antiepileptic drug (AED), brivaracetam (BRV), as adjunctive therapy for adults with refractory partial seizures.Randomized-controlled trials (RCTs) of BRV in the treatment of refractory partial seizure were systematically reviewed and quantified using fixed- or random-effects meta-analysis. 50% responder rate, seizure free rate and adverse events in the treatment period were analyzed as outcomes for measuring efficacy and safety. Pooled effects of risk ratio (RR) and 95% confidence interval (CI) were derived from meta-analysis implemented in RevMan 5.2.Five RCTs were identified for inclusion, and included a total of 1639 patients. The pooled RR of BRV vs. placebo as adjunctive therapy for adults with refractory partial seizure was 1.80 (95% CI 1.43-2.26, P0.00001) for 50% responder rates, 4.11 (95% CI 1.39-12.21, P = 0.01) for seizure free rates, 1.08 (95% CI 0.73-1.59; P = 0.70) for withdrawal rates. There was no evidence of a statistically significant association between the use of BRV and most adverse events, except somnolence (RR 1.63, 95% CI 1.08-2.45, P = 0.02) and fatigue (RR 2.05, 95% CI 1.19-3.53, P = 0.009).This study confirmed significant effects of BRV as adjunctive treatment of refractory partial seizures. This study also demonstrated the good tolerability profile of adjunctive BRV for patients with epilepsy. Further large clinical and pharmacovigilance studies are needed to investigate the long-term efficacy and safety of BRV and, furthermore, to suggest an optimal BRV dosage for clinical use.
- Subjects :
- Adult
Male
medicine.medical_specialty
Drug Resistant Epilepsy
Brivaracetam
Placebo
Epilepsy
Refractory
Internal medicine
Medicine
Humans
Adverse effect
Randomized Controlled Trials as Topic
business.industry
Middle Aged
medicine.disease
Pyrrolidinones
Neurology
Tolerability
Relative risk
Anesthesia
Adjunctive treatment
Anticonvulsants
Drug Therapy, Combination
Female
Neurology (clinical)
Epilepsies, Partial
business
medicine.drug
Subjects
Details
- ISSN :
- 18726844
- Volume :
- 114
- Database :
- OpenAIRE
- Journal :
- Epilepsy research
- Accession number :
- edsair.doi.dedup.....95d16a76ffab55fab40bed500c24d569