Back to Search
Start Over
Phenotypic comparison of allergic airway responses to house dust mite in three rat strains
- Source :
- American Journal of Physiology-Lung Cellular and Molecular Physiology. 284:L588-L598
- Publication Year :
- 2003
- Publisher :
- American Physiological Society, 2003.
-
Abstract
- Brown Norway (BN) rats develop a robust response to antigens in the lung, characterized by a large increase in allergen-specific immune function and pulmonary eosinophilia. The objective of this study was to investigate alternative models by determining whether other rat strains could be sensitized to house dust mite (HDM) antigen and whether the allergic disease process could be worsened with repeated allergen exposure. In general, BN rats sensitized by either subcutaneous or intratracheal routes exhibited increased pulmonary allergy compared with Sprague-Dawley (SD) and Lewis (L) rats. Multiple intratracheal allergen exposures incrementally increased HDM-specific immune function in BN rats but progressively decreased eosinophil recruitment and markers of lung injury. SD rats had more moderate responses, whereas L rats were relatively unresponsive. Because BN rats developed stronger clinical hallmarks of allergic asthma under various immunization regimes compared with SD and L rats, we conclude that the BN is the most appropriate strain for studying allergic asthma-like responses in rats. Phenotypic differences in response to HDM were associated with differences in the Th1/Th2 cytokine balance and antioxidant capacity.
- Subjects :
- Pulmonary and Respiratory Medicine
Allergy
Physiology
Lung injury
medicine.disease_cause
Rats, Sprague-Dawley
Atopy
Interferon-gamma
Allergen
Species Specificity
Rats, Inbred BN
Physiology (medical)
Immunopathology
Hypersensitivity
Animals
Medicine
Lymphocytes
Lung
Pulmonary Eosinophilia
House dust mite
Interleukin-13
biology
business.industry
Pyroglyphidae
Genetic Variation
Cell Biology
Immunoglobulin E
Eosinophil
biology.organism_classification
medicine.disease
Asthma
Rats
respiratory tract diseases
Phenotype
medicine.anatomical_structure
Rats, Inbred Lew
Immunoglobulin G
Immunology
Female
Lymph Nodes
business
Bronchoalveolar Lavage Fluid
Cell Division
Subjects
Details
- ISSN :
- 15221504 and 10400605
- Volume :
- 284
- Database :
- OpenAIRE
- Journal :
- American Journal of Physiology-Lung Cellular and Molecular Physiology
- Accession number :
- edsair.doi.dedup.....95cb6d31f909649f4d3d46c5362e03d4