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Effect of Stress, Adrenocorticotropin or Corticosteroid Treatment, Adrenalectomy, or Hypophysectomy on Hypothalamic Immunoreactive Adrenocorticotropin Concentrations*

Authors :
Michael J. Brownstein
Herbert Hauser
Anthony S. Liotta
Dorothy T. Krieger
Source :
Endocrinology. 105:737-742
Publication Year :
1979
Publisher :
The Endocrine Society, 1979.

Abstract

Despite variations in plasma and/or pituitary ACTH concentrations, no changes in median eminence or medial basal hypothalamic immunoreactive ACTH-like concentrations were seen in rats studied 6 weeks posthypophysectomy, 12 h or 28 days after bilateral adrenalectomy, 6 days after implantation of corticosterone pellets (75 mg), after dexamethasone administration (300 micrograms/100 g BW, ip, twice daily for 4 days), or after chronic immobilization stress. The lack of concordant variation of brain, pituitary, and plasma ACTH concentrations further supports the suggestion of a nonpituitary, central nervous system origin of some portion of brain immunoreactive ACTH-like activity.

Details

ISSN :
19457170 and 00137227
Volume :
105
Database :
OpenAIRE
Journal :
Endocrinology
Accession number :
edsair.doi.dedup.....95c86bb0cac4b0a007d5aba739b86bb0
Full Text :
https://doi.org/10.1210/endo-105-3-737