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Randomized Controlled Trial of DHA Supplementation during Pregnancy: Child Adiposity Outcomes

Authors :
Benjamin Larsen
Elia Escaname
Theresa L. Powell
Sartaj K. Siddiqui
Byron A. Foster
Rajam S. Ramamurthy
John Menchaca
Christian A. Aquino
Daniel E. Hale
Source :
Nutrients; Volume 9; Issue 6; Pages: 566, Nutrients
Publication Year :
2017
Publisher :
Multidisciplinary Digital Publishing Institute, 2017.

Abstract

Investigating safe and effective interventions in pregnancy that lower offspring adiposity is important given the burden of obesity and subsequent metabolic derangements. Our objective was to determine if docosahexaenoic acid (DHA) given during pregnancy to obese mothers results in lower offspring adiposity. This study was a long-term follow-up of a randomized trial of mothers with gestational diabetes or obesity who were randomized to receive DHA supplementation at 800 mg/day or placebo (corn/soy oil) starting at 25–29 weeks gestation. Anthropometric measures were collected at birth and maternal erythrocyte DHA and arachidonic (AA) levels were measured at 26 and 36 weeks gestation. At two- and four-year follow-up time points, offspring adiposity measures along with a diet recall were assessed. A significant increase in erythrocyte DHA levels was observed at 36 weeks gestation in the supplemented group (p < 0.001). While no significant differences by measures of adiposity were noted at birth, two or four years by randomization group, duration of breastfeeding (p < 0.001), and DHA level at 36 weeks (p = 0.002) were associated with body mass index z-score. Our data suggest that DHA supplementation during pregnancy in obese mothers may have long-lasting effects on offspring measures of adiposity.

Details

Language :
English
ISSN :
20726643
Database :
OpenAIRE
Journal :
Nutrients; Volume 9; Issue 6; Pages: 566
Accession number :
edsair.doi.dedup.....95bf7ca3d2266b2fbf1e286347c44e25
Full Text :
https://doi.org/10.3390/nu9060566