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Therapeutic Potential of PPARĪ³ Activation in Stroke
- Source :
- PPAR Research, PPAR Research, Vol 2008 (2008)
- Publication Year :
- 2008
-
Abstract
- Stroke (focal cerebral ischemia) is a leading cause of death and disability among adult population. Many pathological events including inflammation and oxidative stress during the acute period contributes to the secondary neuronal death leading the neurological dysfunction after stroke. Transcriptional regulation of genes that promote these pathophysiological mechanisms can be an effective strategy to minimize the poststroke neuronal death. Peroxisome proliferator-activated receptors (PPARs) are ligand-activated transcription factors known to be upstream to many inflammatory and antioxidant genes. The goal of this review is to discuss the therapeutic potential and putative mechanisms of neuroprotection following PPAR activation after stroke.
- Subjects :
- Ischemia
Peroxisome proliferator-activated receptor
Inflammation
Review Article
Bioinformatics
Neuroprotection
03 medical and health sciences
0302 clinical medicine
Drug Discovery
medicine
Transcriptional regulation
Pharmacology (medical)
lcsh:QH301-705.5
Stroke
Transcription factor
030304 developmental biology
Cause of death
chemistry.chemical_classification
0303 health sciences
business.industry
medicine.disease
lcsh:Biology (General)
chemistry
medicine.symptom
business
030217 neurology & neurosurgery
Subjects
Details
- ISSN :
- 16874757
- Volume :
- 2008
- Database :
- OpenAIRE
- Journal :
- PPAR research
- Accession number :
- edsair.doi.dedup.....95be5e5db96d7ddbdbcce6b6eef61c5c