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Therapeutic Potential of PPARĪ³ Activation in Stroke

Authors :
Raghu Vemuganti
Source :
PPAR Research, PPAR Research, Vol 2008 (2008)
Publication Year :
2008

Abstract

Stroke (focal cerebral ischemia) is a leading cause of death and disability among adult population. Many pathological events including inflammation and oxidative stress during the acute period contributes to the secondary neuronal death leading the neurological dysfunction after stroke. Transcriptional regulation of genes that promote these pathophysiological mechanisms can be an effective strategy to minimize the poststroke neuronal death. Peroxisome proliferator-activated receptors (PPARs) are ligand-activated transcription factors known to be upstream to many inflammatory and antioxidant genes. The goal of this review is to discuss the therapeutic potential and putative mechanisms of neuroprotection following PPAR activation after stroke.

Details

ISSN :
16874757
Volume :
2008
Database :
OpenAIRE
Journal :
PPAR research
Accession number :
edsair.doi.dedup.....95be5e5db96d7ddbdbcce6b6eef61c5c