Back to Search
Start Over
Continuous positive airway pressure acutely increases exercise duration in children with severe therapy-resistant asthma: a randomized crossover trial
- Source :
- World journal of pediatrics : WJP. 17(2)
- Publication Year :
- 2020
-
Abstract
- Lower exercise tolerance is an important component of asthma and the possible effects of non-invasive ventilation on exercise capacity in individuals with severe therapy-resistant asthma (STRA) are unknown. This study aimed to evaluate the immediate effect of continuous positive airway pressure (CPAP) on exercise tolerance in children with STRA. We performed a controlled, randomized, crossover clinical trial including subjects aged 6 to 18 years old diagnosed with STRA. Clinical, anthropometric and lung function data were collected. The participants in the intervention group (IG) used CPAP (PEEP 10cmH2O and FiO2 0.21) for a period of 40 min. Subjects in the control group (CG) used CPAP with minimum PEEP at 1 cmH20 also for 40 min. Afterwards, subjects from both groups underwent cardiopulmonary exercise testing (CPET). After a 15-day washout period, on a subsequent visit, subjects participated in the opposite group to the initial one. Thirteen subjects with a mean age of 12.30 ± 1.7 years were included. The variables of peak expiratory flow (PEF) and forced expiratory volume in the first second (FEV1) before using CPAP and after performing CPET did not show significant differences. Regarding CPET results, there was no significant difference (P = 0.59) between groups at peak exercise for oxygen consumption—VO2 (CG: 33.4 ± 6.3 and IG: 34.5 ± 5.9, mL kg−1 min−1). However, the IG (12.4 ± 2.1) presented a total test time (min) significantly (P = 0.01) longer than the CG (11.5 ± 1.3). The results suggest that the use of CPAP before physical exercise increases exercise duration in children and adolescents with STRA.
- Subjects :
- Male
medicine.medical_specialty
Adolescent
medicine.medical_treatment
Physical exercise
03 medical and health sciences
0302 clinical medicine
030225 pediatrics
Pediatric surgery
medicine
Humans
030212 general & internal medicine
Continuous positive airway pressure
Child
Asthma
Cross-Over Studies
Exercise Tolerance
Continuous Positive Airway Pressure
business.industry
Anthropometry
medicine.disease
Crossover study
respiratory tract diseases
Respiratory Function Tests
Clinical trial
Anesthesia
Pediatrics, Perinatology and Child Health
Breathing
Exercise Test
Female
business
Subjects
Details
- ISSN :
- 18670687
- Volume :
- 17
- Issue :
- 2
- Database :
- OpenAIRE
- Journal :
- World journal of pediatrics : WJP
- Accession number :
- edsair.doi.dedup.....95b6b74f2dc4fe65d520d1866f702b10