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A systematic review of Mycobacterium leprae DNA gyrase mutations and their impact on fluoroquinolone resistance
- Source :
- Clinical Microbiology and Infection, Clinical Microbiology and Infection, 2021, ⟨10.1016/j.cmi.2021.07.007⟩, Clinical Microbiology and Infection, Elsevier for the European Society of Clinical Microbiology and Infectious Diseases, 2021, ⟨10.1016/j.cmi.2021.07.007⟩
- Publication Year :
- 2021
- Publisher :
- HAL CCSD, 2021.
-
Abstract
- Background The fact that Mycobacterium leprae does not grow in vitro remains a challenge in the survey of its antimicrobial resistance (AMR). Mainly molecular methods are used to diagnose AMR in M. leprae to provide reliable data concerning mutations and their impact. Fluoroquinolones (FQs) are efficient for the treatment of leprosy and the main second-line drugs in case of multidrug resistance. Objectives This study aimed at performing a systematic review (a) to characterize all DNA gyrase gene mutations described in clinical isolates of M. leprae, (b) to distinguish between those associated with FQ resistance or susceptibility and (c) to delineate a consensus numbering system for M. leprae GyrA and GyrB. Data sources Data source was PubMed. Study eligibility criteria Publications reporting genotypic susceptibility-testing methods and gyrase gene mutations in M. leprae clinical strains. Results In 25 studies meeting our inclusion criteria, 2884 M. leprae isolates were analysed (2236 for gyrA only (77%) and 755 for both gyrA and gyrB (26%)): 3.8% of isolates had gyrA mutations (n = 110), mostly at position 91 (n = 75, 68%) and 0.8% gyrB mutations (n = 6). Since we found discrepancies regarding the location of substitutions associated with FQ resistance, we established a consensus numbering system to properly number the mutations. We also designed a 3D model of the M. leprae DNA gyrase to predict the impact of mutations whose role in FQ-susceptibility has not been demonstrated previously. Conclusions Mutations in DNA gyrase are observed in 4% of the M. leprae clinical isolates. To solve discrepancies among publications and to distinguish between mutations associated with FQ resistance or susceptibility, the consensus numbering system we proposed as well as the 3D model of the M. leprae gyrase for the evaluation of the impact of unknown mutations in FQ resistance, will provide help for resistance surveillance.
- Subjects :
- Microbiology (medical)
[SDV.IMM] Life Sciences [q-bio]/Immunology
Microbial Sensitivity Tests
Biology
Gene mutation
DNA gyrase
03 medical and health sciences
Antibiotic resistance
Drug Resistance, Bacterial
Genotype
Humans
fluoroquinolones
Mycobacterium leprae
Resistance substitutions
GyrA
030304 developmental biology
GyrB
Genetics
0303 health sciences
Numbering system
030306 microbiology
General Medicine
biology.organism_classification
Fluoroquinolone resistance
3. Good health
Multiple drug resistance
Infectious Diseases
DNA Gyrase
Mutation
[SDV.IMM]Life Sciences [q-bio]/Immunology
Mutations
Subjects
Details
- Language :
- English
- ISSN :
- 1198743X and 14690691
- Database :
- OpenAIRE
- Journal :
- Clinical Microbiology and Infection, Clinical Microbiology and Infection, 2021, ⟨10.1016/j.cmi.2021.07.007⟩, Clinical Microbiology and Infection, Elsevier for the European Society of Clinical Microbiology and Infectious Diseases, 2021, ⟨10.1016/j.cmi.2021.07.007⟩
- Accession number :
- edsair.doi.dedup.....95b5daaafb33e67d8d32cb1f5bd20cca