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Effects of mobile phone type signals on calcium levels within human leukaemic T-cells (Jurkat cells)
- Source :
- International Journal of Radiation Biology. 77:1207-1217
- Publication Year :
- 2001
- Publisher :
- Informa UK Limited, 2001.
-
Abstract
- To test whether exposure to simulated GSM mobile phone signals (915 MHz, 2 W x kg(-1)) influences the concentration of calcium or calcium signalling patterns in a human lymphocyte cell line.The radiofrequency (RF) energy was delivered via a coaxial applicator to a perfused chamber where cells adherent to a thin glass coverslip were imaged by laser scanning confocal microscopy. Cell calcium concentration, estimated from Fluo-3 fluorescence, was monitored over two 10-min periods; control followed by exposed/sham, with exposure status assigned in a blind and randomized fashion. Both continuous wave (CW) and pulsed wave (PW) RF (on both phytohaemagglutanin-activated and unactivated cells) were studied (with an equal number of sham exposures) on 100 cells per category (total 800 cells).No significant changes were noted for the following: regression slope of calcium fluorescence; mean calcium concentration; number of calcium 'spikes' in each 10 min; or mean height of these 'spikes'. The average frequency from Fourier spectra of these periods showed significant alteration in one category only: PW exposure of activated cells.There is no clear indication that RF emissions from mobile phones are associated with any changes in calcium levels or calcium signalling in lymphocytes.
- Subjects :
- Time Factors
T-Lymphocytes
Confocal
chemistry.chemical_element
Calcium
Jurkat cells
Jurkat Cells
Electromagnetic Fields
Microscopy
Humans
Radiology, Nuclear Medicine and imaging
Coloring Agents
Microwaves
Radiometry
Calcium signaling
Calcium metabolism
Aniline Compounds
Leukemia
Microscopy, Confocal
Models, Statistical
Radiological and Ultrasound Technology
Temperature
T lymphocyte
Telephone
Xanthenes
chemistry
Cell culture
Signal Transduction
Biomedical engineering
Subjects
Details
- ISSN :
- 13623095 and 09553002
- Volume :
- 77
- Database :
- OpenAIRE
- Journal :
- International Journal of Radiation Biology
- Accession number :
- edsair.doi.dedup.....95ac97d35992089d02416a0a9135331c