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Studies of Monoclonal Antibodies Specific for Major Histocompatibility Complex Products of the Rat
- Source :
- Scandinavian Journal of Immunology. 21:549-563
- Publication Year :
- 2006
- Publisher :
- Wiley, 2006.
-
Abstract
- Sixteen monoclonal antibodies against antigens coded for by the RT1 complex of the rat have been produced. Fourteen are specific for the a haplotype: six recognize class II and eight class I antigens. Two are specific for the 1 haplotype, one reacting with class I and the other with class II antigens. By means of these monoclonal antibodies four independent clusters of antigens for class I antigens of the a haplotype and three for class II antigens could be defined. The three antigenic sites of class II antigens reside on the same heterodimer. The monoclonals described here are characterized with regard to Ig class and subclass, pI, and complement-activating capacity.
- Subjects :
- Male
medicine.drug_class
Immunology
Immunoglobulins
Major histocompatibility complex
Monoclonal antibody
Binding, Competitive
Subclass
Antigen-Antibody Reactions
Antigen
Antibody Specificity
Histocompatibility Antigens
Rats, Inbred BN
medicine
Animals
biology
Haplotype
Class I Antigens
Antibodies, Monoclonal
General Medicine
Cytotoxicity Tests, Immunologic
Precipitin Tests
Molecular biology
Rats
Rats, Inbred ACI
Rats, Inbred Lew
biology.protein
Female
Lymphocyte Culture Test, Mixed
Class II Antigens
Subjects
Details
- ISSN :
- 03009475
- Volume :
- 21
- Database :
- OpenAIRE
- Journal :
- Scandinavian Journal of Immunology
- Accession number :
- edsair.doi.dedup.....959ad700cba0a7ae51cc633401f5844a