Back to Search
Start Over
Incidence of influenza A(H3N2) virus infections in Hong Kong in a longitudinal sero-epidemiological study, 2009-2015
- Source :
- PLoS ONE, PLoS ONE, Vol 13, Iss 5, p e0197504 (2018)
- Publication Year :
- 2018
- Publisher :
- Public Library of Science (PLoS), 2018.
-
Abstract
- BackgroundMany serologic studies were done during and after the 2009 influenza pandemic, to estimate the cumulative incidence of influenza A(H1N1)pdm09 virus infections, but there are few comparative estimates of the incidence of influenza A(H3N2) virus infections during epidemics.MethodsWe conducted a longitudinal serologic study in Hong Kong. We collected sera annually and tested samples from 2009-13 by HAI against the A/Perth/16/2009(H3N2) virus, and samples from 2013-15 against the A/Victoria/361/2011(H3N2) virus using the hemagglutination inhibition (HAI) assay. We estimated the cumulative incidence of infections based on 4-fold or greater rises in HAI titers in consecutive sera.ResultsThere were four major H3N2 epidemics: (1) Aug-Oct 2010; (2) Mar-Jun 2012; (3) Jul-Oct 2013; and (4) Jun-Jul 2014. Between 516 and 619 relevant pairs of sera were available for each epidemic. We estimated that 9%, 19%, 7% and 7% of the population were infected in each epidemic, respectively, with higher incidence in children in epidemics 1 and 4.ConclusionsWe found that re-infections in each of the four H3N2 epidemics that occurred from 2010 through 2014 were rare. The largest H3N2 epidemic occurred with the lowest level of pre-epidemic immunity.
- Subjects :
- Male
RNA viruses
0301 basic medicine
Influenza Viruses
Viral Diseases
Physiology
viruses
Pathology and Laboratory Medicine
medicine.disease_cause
Biochemistry
Geographical locations
Cohort Studies
0302 clinical medicine
Seroepidemiologic Studies
Immune Physiology
Medicine and Health Sciences
Influenza A virus
Medicine
Public and Occupational Health
Cumulative incidence
030212 general & internal medicine
Child
Aged, 80 and over
education.field_of_study
Immune System Proteins
Multidisciplinary
Incidence
Incidence (epidemiology)
virus diseases
Middle Aged
Viral Load
Vaccination and Immunization
3. Good health
Vaccination
Infectious Diseases
Serology
Medical Microbiology
Child, Preschool
Population Surveillance
Viral Pathogens
Viruses
Hong Kong
Female
Disease Susceptibility
Seasons
Pathogens
Viral load
Research Article
Adult
Asia
Adolescent
Science
Immunology
Population
History, 21st Century
Microbiology
Antibodies
Virus
Young Adult
03 medical and health sciences
Influenza, Human
Humans
education
Microbial Pathogens
Aged
Hemagglutination assay
Biology and life sciences
business.industry
Influenza A Virus, H3N2 Subtype
Organisms
Immunity
Proteins
Virology
Influenza
030104 developmental biology
Age Groups
Population Groupings
Preventive Medicine
People and places
business
Orthomyxoviruses
Subjects
Details
- ISSN :
- 19326203
- Volume :
- 13
- Database :
- OpenAIRE
- Journal :
- PLOS ONE
- Accession number :
- edsair.doi.dedup.....9598a31e5f1dfa0c5819ba8d574115e5