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Incidence and Clearance of Penile High-Risk Human Papillomavirus Infection and Their Determinants Among HIV-Negative Men Who Have Sex With Men
- Source :
- Nadar, H J, van Bilsen, W P H, Marra, E, Bruisten, S, Heideman, D A M & Schim van der Loeff, M F 2021, ' Incidence and Clearance of Penile High-Risk Human Papillomavirus Infection and Their Determinants Among HIV-Negative Men Who Have Sex With Men ', Sexually Transmitted Diseases, vol. 48, no. 11, pp. 864-872 . https://doi.org/10.1097/OLQ.0000000000001455, Sexually Transmitted Diseases, 48(11), 864-872. Lippincott Williams and Wilkins, Sexually transmitted diseases, 48(11), 864-872. Lippincott Williams and Wilkins
- Publication Year :
- 2021
-
Abstract
- BACKGROUND: Men who have sex with men (MSM) are at increased risk of anogenital human papillomavirus (HPV) infections. We aimed to assess the incidence and clearance of penile high-risk HPV (hrHPV) infections and their determinants among HIV-negative MSM living in the Netherlands. METHODS: Between 2010 and 2015, HIV-negative MSM were semiannually tested for penile HPV and completed detailed questionnaires on health and sexual behavior. Self-collected penile swabs were tested for HPV DNA using SPF10-PCR DEIA/LiPA25 system. Type-specific hrHPV incidence (IR) and clearance rates (CR) were calculated for 12 hrHPV types (HPV-16, HPV-18, HPV-31, HPV-33, HPV-35, HPV-39, HPV-45, HPV-51, HPV-52, HPV-56, HPV-58, and HPV-59). Determinants of incidence and clearance of HPV-16 and HPV-18, separately, and combined 7 hrHPV types covered by the nonavalent vaccine were assessed by Poisson regression using generalized estimating equations for combined hrHPV types. RESULTS: We included 638 HIV-negative MSM, with a median age of 38 (interquartile range, 33-43) years. HPV-16 had an IR of 4.9/1000 person-months of observation at risk (PMO; 95% confidence interval [95% CI], 3.8-6.3) and CR of 90.6/1000 PMO (95% CI, 60.7-135.1). The IR and CR of HPV-18 were 3.4/1000 PMO (95% CI, 2.5-4.5) and 119.2/1000 PMO (95% CI, 76.9-184.8), respectively. Age and condom use during insertive anal sex were not associated with hrHPV incidence, whereas high number of recent sex partners was. CONCLUSIONS: The relatively high IR and low CR of penile HPV-16 and HPV-18 among HIV-negative MSM correlates with their high prevalence and oncogenic potential. Incident HPV infections were associated with recent sexual risk behavior.
- Subjects :
- Microbiology (medical)
Adult
Male
medicine.medical_specialty
Sexual Behavior
Human immunodeficiency virus (HIV)
Anal Canal
HIV Infections
Dermatology
medicine.disease_cause
law.invention
Men who have sex with men
symbols.namesake
Sexual and Gender Minorities
Condom
law
Interquartile range
Risk Factors
Internal medicine
Prevalence
Medicine
Humans
Poisson regression
Homosexuality, Male
Generalized estimating equation
Papillomaviridae
business.industry
Incidence (epidemiology)
Incidence
Papillomavirus Infections
Public Health, Environmental and Occupational Health
virus diseases
Confidence interval
female genital diseases and pregnancy complications
Infectious Diseases
symbols
business
Subjects
Details
- Language :
- English
- ISSN :
- 01485717
- Database :
- OpenAIRE
- Journal :
- Nadar, H J, van Bilsen, W P H, Marra, E, Bruisten, S, Heideman, D A M & Schim van der Loeff, M F 2021, ' Incidence and Clearance of Penile High-Risk Human Papillomavirus Infection and Their Determinants Among HIV-Negative Men Who Have Sex With Men ', Sexually Transmitted Diseases, vol. 48, no. 11, pp. 864-872 . https://doi.org/10.1097/OLQ.0000000000001455, Sexually Transmitted Diseases, 48(11), 864-872. Lippincott Williams and Wilkins, Sexually transmitted diseases, 48(11), 864-872. Lippincott Williams and Wilkins
- Accession number :
- edsair.doi.dedup.....95920547c571cdc8854d89ff4b984f19