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Seroprevalence of cutaneous human papillomaviruses (HPVs) among men in the multinational HPV Infection in Men study
- Source :
- Journal of General Virology. 97:3291-3301
- Publication Year :
- 2016
- Publisher :
- Microbiology Society, 2016.
-
Abstract
- Data on cutaneous human papillomavirus (HPV) seroprevalence are primarily derived from skin cancer case–control studies. Few studies have reported the seroprevalence of cutaneous HPV among healthy men. This study investigated the seroprevalence of cutaneous HPV types and associated risk factors among men residing in Brazil, Mexico and the USA. Six hundred men were randomly selected from the HPV Infection in Men study. Archived serum specimens were tested for antibodies against 14 cutaneous HPV genotypes, β-HPV types (5/8/12/14/17/22/23/24/38/48), α-HPV 27, γ-HPV 4, µ-HPV1 and ν-HPV 41 using a glutathione S-transferase L1-based multiplex serology assay. Risk factor data were collected by a questionnaire. Binomial proportions were used to estimate seroprevalence, and logistic regression to examine factors associated with seropositivity. Overall, 65.4 % of men were seropositive to ≥1 of the 14 cutaneous HPV types, and 39.0 % were positive for ≥1 β-HPV types. Seroprevalence was 8.9, 30.9, 28.6 and 9.4 % for α-HPV 27, γ-HPV 4, µ-HPV 1 and ν-HPV 41, respectively. In multivariate analyses, seropositivity for any cutaneous HPV type was associated with higher education [adjusted odds ratio (AOR) 1.75; 95 % confidence interval (CI) 1.08–2.83], and seropositivity of any β-HPV type was significantly associated with increasing age (AOR 1.72; 95 % CI 1.12–2.63, for men aged 31–44 years vs men aged 18–30 years). Other factors associated with various type-specific cutaneous HPV seropositivity included country, circumcision and lifetime number of male sexual partners. These data indicate that exposure to cutaneous HPV is common. Future studies are needed to assess the role of cutaneous HPV in diseases.
- Subjects :
- Adult
Male
0301 basic medicine
Adolescent
Population
Antibodies, Viral
Skin Diseases
Serology
Young Adult
03 medical and health sciences
0302 clinical medicine
Seroepidemiologic Studies
Virology
medicine
Humans
Seroprevalence
Prospective Studies
Papillomaviridae
Risk factor
education
Mexico
Aged
education.field_of_study
biology
Papillomavirus Infections
HPV infection
Case-control study
virus diseases
Odds ratio
Middle Aged
medicine.disease
biology.organism_classification
Standard
female genital diseases and pregnancy complications
030104 developmental biology
Case-Control Studies
030220 oncology & carcinogenesis
Female
Brazil
Subjects
Details
- ISSN :
- 14652099 and 00221317
- Volume :
- 97
- Database :
- OpenAIRE
- Journal :
- Journal of General Virology
- Accession number :
- edsair.doi.dedup.....9587d8ea140a13cccea6c83b59b3f33d