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Impaired signalling pathways mediated by extracellular vesicles in diabesity
- Source :
- Molecular Aspects of Medicine. 66:13-20
- Publication Year :
- 2019
- Publisher :
- Elsevier BV, 2019.
-
Abstract
- Diabesity, obesity, and type 2 diabetes mellitus (T2DM) are the most prevalent diseases nowadays and associate with high risk of cardiovascular complications. The impaired signalling pathways associated with the metabolism of D-glucose, lipids, and insulin have been studied for many years aiming to understand the cellular mechanisms of these diseases. Extracellular vesicles (EVs), including exosomes and microvesicles, carry different microRNAs or proteins as cargoes, acting as a mechanism of cell-to-cell communication to modulate different cell functions altering the metabolic regulatory pathways. Several studies have shown an altered number or cargo of EVs in metabolic diseases, including T2DM and obesity, suggesting that these vesicles may play an important role in the regulation of metabolic signalling pathways in diabesity. In this review, we described some of the current studies involving EVs and hypothesize about the role of these structures in the impaired metabolism in T2DM, obesity, and diabesity.
- Subjects :
- 0301 basic medicine
medicine.medical_treatment
Clinical Biochemistry
Cell Communication
Biology
Biochemistry
Extracellular vesicles
Extracellular Vesicles
03 medical and health sciences
0302 clinical medicine
Diabetes mellitus
microRNA
medicine
Humans
Gene Regulatory Networks
Obesity
Molecular Biology
Mechanism (biology)
Insulin
Type 2 Diabetes Mellitus
General Medicine
Metabolism
medicine.disease
Microvesicles
Cell biology
030104 developmental biology
Diabetes Mellitus, Type 2
030220 oncology & carcinogenesis
Molecular Medicine
Signal Transduction
Subjects
Details
- ISSN :
- 00982997
- Volume :
- 66
- Database :
- OpenAIRE
- Journal :
- Molecular Aspects of Medicine
- Accession number :
- edsair.doi.dedup.....95742b3acf881a29fcc9cb764b7fd34d