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Neutralizing-antibody-independent SARS-CoV-2 control correlated with intranasal-vaccine-induced CD8
- Source :
- Cell Reports Medicine
- Publication Year :
- 2021
-
Abstract
- Effective vaccines are essential for the control of the COVID-19 pandemic. Currently-developed vaccines inducing SARS-CoV-2 spike (S) antigen-specific neutralizing antibodies (NAbs) are effective, but the appearance of NAb-resistant S variant viruses is of great concern. A vaccine inducing S-independent or NAb-independent SARS-CoV-2 control may contribute to containment of these variants. Here, we investigate the efficacy of an intranasal vaccine expressing viral non-S antigens against intranasal SARS-CoV-2 challenge in cynomolgus macaques. Seven vaccinated macaques exhibit significantly reduced viral load in nasopharyngeal swabs on day 2 post-challenge compared to nine unvaccinated controls. The viral control in the absence of SARS-CoV-2-specific NAbs is significantly correlated with vaccine-induced viral antigen-specific CD8+ T-cell responses. Our results indicate that CD8+ T-cell induction by intranasal vaccination can result in NAb-independent control of SARS-CoV-2 infection, highlighting a potential of vaccine-induced CD8+ T-cell responses to contribute to COVID-19 containment.<br />Graphical Abstract<br />Ishii et al. show neutralization-independent SARS-CoV-2 control associated with vaccine-induced CD8+ T-cell responses, indicating that virus-specific CD8+ T-cell induction by intranasal vaccination can result in SARS-CoV-2 control. Results highlight the potential of vaccine-induced CD8+ T-cell responses to contribute to the control of SARS-CoV-2 variants.
- Subjects :
- Male
COVID-19 Vaccines
Coronavirus M Proteins
viruses
CD8-Positive T-Lymphocytes
Antibodies, Viral
General Biochemistry, Genetics and Molecular Biology
Coronavirus Envelope Proteins
Report
vaccine
Chlorocebus aethiops
Animals
Coronavirus Nucleocapsid Proteins
Pandemics
Vero Cells
Administration, Intranasal
SARS-CoV-2
viral vector
Vaccination
COVID-19
Viral Load
Phosphoproteins
Antibodies, Neutralizing
Disease Models, Animal
Macaca fascicularis
Treatment Outcome
variant
Spike Glycoprotein, Coronavirus
Female
CD8+ T cell
Subjects
Details
- ISSN :
- 26663791
- Volume :
- 3
- Issue :
- 2
- Database :
- OpenAIRE
- Journal :
- Cell reports. Medicine
- Accession number :
- edsair.doi.dedup.....956377056f5082668b87d46e036cb0f6