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Simultaneous hyperbaric oxygen therapy during systemic chemotherapy reverses chemotherapy-induced peripheral neuropathy by inhibiting TLR4 and TRPV1 activation in the central and peripheral nervous system
- Source :
- Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer. 29(11)
- Publication Year :
- 2020
-
Abstract
- Chemotherapy-induced peripheral neuropathy (CIPN) is considered one of the most common sequelae in patients with cancer who experience consistent abnormal sensations or pain symptoms during or after paclitaxel (PAC) chemotherapy. Transient receptor potential vanilloid 1 (TRPV1) and toll-like receptor 4 (TLR4) have been reported to interact in the nervous system in patients with CIPN. The antinociceptive effects of hyperbaric oxygen therapy (HBOT) on CIPN was demonstrated in this study through behavior tests. Using a CIPN rat model, we examined the effects of simultaneous HBOT (SHBOT) administration during chemotherapy and discovered that SHBOT achieved better reversal effects than chemotherapy alone. Twenty-four rats were randomly allocated to four groups: control, PAC, SHBOT, and HBOT after PAC groups. Behavior tests were performed to evaluate mechanical allodynia and thermal hyperalgesia status. Tissues from the spinal cord and dorsal root ganglions were collected, and TLR4 and TRPV1 expression and microglial activation were investigated through immunofluorescence (IF) staining. The mechanical and thermal behavior tests revealed that HBOT intervention during PAC treatment led to the early alleviation of CIPN symptoms and inhibited CIPN deterioration. IF staining revealed that TLR4, TRPV1, and microglial activation were all upregulated in PAC-injected rats and exhibited early and significant downregulation in SHBOT-treated rats. This study is the first to demonstrate that the use of SHBOT during PAC treatment has potential for the early suppression of CIPN initiation and deterioration, indicating that it can alleviate CIPN symptoms and may reverse CIPN in patients undergoing systemic chemotherapy.
- Subjects :
- Nervous system
Paclitaxel
medicine.medical_treatment
TRPV1
TRPV Cation Channels
Antineoplastic Agents
Pharmacology
03 medical and health sciences
0302 clinical medicine
Ganglia, Spinal
medicine
Animals
Humans
030212 general & internal medicine
Chemotherapy
Hyperbaric Oxygenation
business.industry
Peripheral Nervous System Diseases
medicine.disease
Rats
Toll-Like Receptor 4
Peripheral neuropathy
medicine.anatomical_structure
Nociception
Oncology
Chemotherapy-induced peripheral neuropathy
030220 oncology & carcinogenesis
Peripheral nervous system
TLR4
business
Subjects
Details
- ISSN :
- 14337339
- Volume :
- 29
- Issue :
- 11
- Database :
- OpenAIRE
- Journal :
- Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer
- Accession number :
- edsair.doi.dedup.....9551d1be062cfd1ea631fece57f2f9d4