Back to Search
Start Over
Discovery of human CCR5 antagonists containing hydantoins for the treatment of HIV-1 infection
- Source :
- Bioorganic & Medicinal Chemistry Letters. 11:3099-3102
- Publication Year :
- 2001
- Publisher :
- Elsevier BV, 2001.
-
Abstract
- A series of hydantoin derivatives has been discovered as highly potent nonpeptide antagonists for the human CCR5 receptor. The synthesis, SAR, and biological profiles of this class of antagonists are described.
- Subjects :
- Anti-HIV Agents
Chemokine receptor CCR5
Clinical Biochemistry
Human immunodeficiency virus (HIV)
Pharmaceutical Science
HIV Infections
Pharmacology
medicine.disease_cause
Biochemistry
Chemical synthesis
Virus
Drug Discovery
medicine
Humans
skin and connective tissue diseases
Molecular Biology
biology
Chemistry
Hydantoins
fungi
Organic Chemistry
biology.organism_classification
In vitro
body regions
CCR5 Receptor Antagonists
Lentivirus
Benzene derivatives
HIV-1
Hydantoin derivatives
biology.protein
Molecular Medicine
Subjects
Details
- ISSN :
- 0960894X
- Volume :
- 11
- Database :
- OpenAIRE
- Journal :
- Bioorganic & Medicinal Chemistry Letters
- Accession number :
- edsair.doi.dedup.....954f5410b72cde5cf716b0ba6a4a342b
- Full Text :
- https://doi.org/10.1016/s0960-894x(01)00654-0