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The Association of Autoimmune Diseases with Type 1 Diabetes Mellitus in Children Depends Also by the Length of Partial Clinical Remission Phase (Honeymoon)
- Source :
- International Journal of Endocrinology, Vol 2020 (2020), International Journal of Endocrinology
- Publication Year :
- 2020
- Publisher :
- Hindawi, 2020.
-
Abstract
- Type 1 diabetes mellitus (DM) is characterized by irreversible, autoimmune, pancreatic β-cell destruction. During the disease, some patients experience a phase of Partial Clinical Remission (PCR) known as “honeymoon.” This is a transitory period that is characterized by insulin production by residual β cells following DM diagnosis and initiating the insulin therapy. In this study, we aimed to evaluate the influence of insulin production on immune system after the onset of diabetes, and we showed that the duration of honeymoon period could be related to the onset of other autoimmune conditions. For this retrospective study, 159 children aged between 11 and 18 years with type 1 DM were eligible. They have been diagnosed diabetes at least 10 years ago and use exogenous insulin. Our results showed that younger age at the onset of Type 1 DM in children, predicts Celiac Disease. Female sex and low HCO3 levels at the onset of DM had a high predictive value on patients who did not experience longer Partial Clinical Remission phase. Patients with higher BMI at the diagnosis of DM experienced shorter honeymoon period than the average. Smaller of our patients who diagnosed just DM have more than 297 days honeymoon period with respect to patients with one associated autoimmune disease. This may be due to a continuous and prolonged stimulation of immune system during the period of honeymoon that predispose the patient to develop other TH1 diseases. The patients who experienced more than 297 days Partial Clinical Remission seem under risk of developing one other autoimmune disease more than the patients who experienced less than 297 days Partial Clinical Remission. We have to consider that this observation is very intriguing because many protocols spring-up to try prolonging the honeymoon period in patients with autoimmune DM. If this aim is important from a metabolic point of view, long follow-ups are needed to be sure that the risk of other autoimmune diseases does not increase.
- Subjects :
- Pediatrics
medicine.medical_specialty
Article Subject
Endocrinology, Diabetes and Metabolism
medicine.medical_treatment
030209 endocrinology & metabolism
Disease
Diseases of the endocrine glands. Clinical endocrinology
03 medical and health sciences
0302 clinical medicine
Endocrinology
Immune system
Diabetes mellitus
Remission phase
medicine
030212 general & internal medicine
Autoimmune disease
Type 1 diabetes
Endocrine and Autonomic Systems
business.industry
Insulin
Retrospective cohort study
medicine.disease
RC648-665
business
Research Article
Subjects
Details
- Language :
- English
- ISSN :
- 16878337
- Database :
- OpenAIRE
- Journal :
- International Journal of Endocrinology
- Accession number :
- edsair.doi.dedup.....954e27d6a6ae7f9f2ce27f666ef4287b
- Full Text :
- https://doi.org/10.1155/2020/2630827