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From Small Molecules toward Whole Cells Detection: Application of Electrochemical Aptasensors in Modern Medical Diagnostics
- Source :
- Sensors, Vol 21, Iss 724, p 724 (2021), Sensors (Basel, Switzerland)
- Publication Year :
- 2021
- Publisher :
- MDPI AG, 2021.
-
Abstract
- This paper focuses on the current state of art as well as on future trends in electrochemical aptasensors application in medical diagnostics. The origin of aptamers is presented along with the description of the process known as SELEX. This is followed by the description of the broad spectrum of aptamer-based sensors for the electrochemical detection of various diagnostically relevant analytes, including metal cations, abused drugs, neurotransmitters, cancer, cardiac and coagulation biomarkers, circulating tumor cells, and viruses. We described also possible future perspectives of aptasensors development. This concerns (i) the approaches to lowering the detection limit and improvement of the electrochemical aptasensors selectivity by application of the hybrid aptamer–antibody receptor layers and/or nanomaterials; and (ii) electrochemical aptasensors integration with more advanced microfluidic devices as user-friendly medical instruments for medical diagnostic of the future.
- Subjects :
- Medical diagnostic
Materials science
cancer biomarkers
metal cations
Aptamer
Nanotechnology
Review
Biosensing Techniques
02 engineering and technology
Electrochemical detection
lcsh:Chemical technology
01 natural sciences
Biochemistry
Antibodies
Analytical Chemistry
medical diagnostics
Broad spectrum
Humans
lcsh:TP1-1185
Electrical and Electronic Engineering
Instrumentation
microbial toxins
SELEX
010401 analytical chemistry
Medical instruments
aptasensors
Aptamers, Nucleotide
021001 nanoscience & nanotechnology
Small molecule
Atomic and Molecular Physics, and Optics
Nanostructures
0104 chemical sciences
electrochemistry
State of art
0210 nano-technology
Biomarkers
Systematic evolution of ligands by exponential enrichment
Subjects
Details
- ISSN :
- 14248220
- Volume :
- 21
- Database :
- OpenAIRE
- Journal :
- Sensors
- Accession number :
- edsair.doi.dedup.....953c0a8a665edcee565448a3450cddef