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Assembly of Fluorescent Polymer Nanoparticles Using Different Microfluidic Mixers
- Source :
- Langmuir, Langmuir, 2022, ⟨10.1021/acs.langmuir.2c00534⟩
- Publication Year :
- 2022
- Publisher :
- HAL CCSD, 2022.
-
Abstract
- Nanoprecipitation is a facile and efficient approach to the assembly of loaded polymer nanoparticles (NPs) for applications in bioimaging and targeted drug delivery. Their successful use in clinics requires reproducible and scalable synthesis, for which microfluidics appears as an attractive technique. However, in the case of nanoprecipitation, particle formation depends strongly on mixing. Here, we compare 5 different types of microfluidic mixers with respect to the formation and properties of poly(d-l-lactide--glycolide) (PLGA) and poly(methyl methacrylate) NPs loaded with a fluorescent dye salt: a cross-shaped mixer, a multilamination mixer, a split and recombine mixer, two herringbone mixers, and two impact jet mixers. Size and fluorescence properties of the NPs obtained with these mixers are evaluated. All mixers, except the cross-shaped one, yield NPs at least as small and fluorescent as those obtained manually. Notably in the case of impact jet mixers operated at high flow speeds, the size of the NPs could be strongly reduced from >50 nm down to 70%. These results show the importance of precisely controlling the assembly conditions for loaded polymer NPs. The present work further provides guidance for choosing the optimal microfluidic setup for production of nanomaterials for biomedical applications.
- Subjects :
- [CHIM.POLY] Chemical Sciences/Polymers
Polymers
Microfluidics
Surfaces and Interfaces
Fluorescent nanoparticles
Condensed Matter Physics
Drug Delivery Systems
Polymer nanoparticles
Size control
[CHIM.POLY]Chemical Sciences/Polymers
Electrochemistry
Nanoparticles
General Materials Science
Particle Size
Nanoprecipitation
Spectroscopy
Fluorescent Dyes
Subjects
Details
- Language :
- English
- ISSN :
- 07437463 and 15205827
- Database :
- OpenAIRE
- Journal :
- Langmuir, Langmuir, 2022, ⟨10.1021/acs.langmuir.2c00534⟩
- Accession number :
- edsair.doi.dedup.....953791d69af01d8b0aed0d6b83890693