Back to Search
Start Over
Emerging pollutants and plants - metabolic activation of diclofenac by peroxidases
- Source :
- Chemosphere 146, 435-441 (2016)
- Publication Year :
- 2016
- Publisher :
- Pergamon-elsevier Science Ltd, 2016.
-
Abstract
- Human pharmaceuticals and their residues are constantly detected in our waterbodies, due to poor elimination rates, even in the most advanced waste water treatment plants. Their impact on the environment and human health still remains unclear. When phytoremediation is applied to aid water treatment, plants may transform and degrade xenobiotic contaminants through phase I and phase II metabolism to more water soluble and less toxic intermediates. In this context, peroxidases play a major role in activating compounds during phase I via oxidation. In the present work, the ability of a plant peroxidase to oxidize the human painkiller diclofenac was confirmed using stopped flow spectroscopy in combination with LC-MS analysis. Analysis of an orange colored product revealed the structure of the highly reactive Diclofenac-2,5-Iminoquinone, which may be the precursor of several biological conjugates and breakdown products in planta.
- Subjects :
- Diclofenac
Environmental Engineering
Health, Toxicology and Mutagenesis
Wastewater
010501 environmental sciences
01 natural sciences
Armoracia
Water Purification
Activation, Metabolic
chemistry.chemical_compound
Tandem Mass Spectrometry
medicine
Humans
Environmental Chemistry
Chromatography, High Pressure Liquid
Horseradish Peroxidase
0105 earth and related environmental sciences
Pollutant
biology
Chemistry
010401 analytical chemistry
Public Health, Environmental and Occupational Health
General Medicine
General Chemistry
Contamination
Pollution
0104 chemical sciences
Phytoremediation
Biodegradation, Environmental
Environmental chemistry
Iminoquinone
Lc-ms
Peroxidase
Stopped Flow Spectroscopy
biology.protein
Water treatment
Sewage treatment
Xenobiotic
Oxidation-Reduction
Water Pollutants, Chemical
medicine.drug
Subjects
Details
- Language :
- German
- Database :
- OpenAIRE
- Journal :
- Chemosphere 146, 435-441 (2016)
- Accession number :
- edsair.doi.dedup.....9532b8b2c917ebec61ae7fd1b47f0f4d