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Reduced Urinary Excretion of Epidermal Growth Factor in Incipient and Overt Diabetic Nephropathy
- Source :
- Diabetic Medicine. 6:121-126
- Publication Year :
- 1989
- Publisher :
- Wiley, 1989.
-
Abstract
- To study the relationship between glomerular and tubular function we investigated glomerular filtration rate (GFR), urinary albumin excretion, and urinary excretion of epidermal growth factor (EGF, a mitogenic peptide synthesized in the renal tubular cells) in normal subjects (group I, n = 7) and in Type 1 (insulin-dependent) diabetic patients with normoalbuminuria (group II, n = 11); with incipient nephropathy (microalbuminuria) (group III, n = 9); with nephropathy and normal GFR (group IV, n = 12); and with reduced GFR (group V, n = 8). EGF (nmol 24 h-1) decreased with progressive glomerular involvement, from 7.9 (4.1-10.5) (median and range) in group I, to 6.7 (1.3-9.2) in group II, 5.0 (3.6-7.4) in group III, 4.1 (2.5-9.5) in group IV, and 1.1 (0.1-2.5) in group V. The urinary excretion of EGF was significantly reduced in patients with elevated UAE (group III, IV, and V) compared with normal control subjects (p less than 0.05). A significant correlation between urinary excretion of EGF and GFR (r = 0.71, p less than 0.001) and an inverse correlation between the urinary excretion of EGF and albumin (r = -0.35, p less than 0.05) was demonstrated in the Type 1 diabetic patients with GFR greater than 90 ml min-1. Our study demonstrates that urinary excretion of epidermal growth factor diminishes with increasing nephron impairment, and that renal tubular function as judged by the excretion of EGF is reduced early in the development of diabetic kidney disease.
- Subjects :
- Adult
Male
medicine.medical_specialty
Endocrinology, Diabetes and Metabolism
Renal function
Nephron
Nephropathy
Diabetic nephropathy
Excretion
Endocrinology
Reference Values
Epidermal growth factor
Internal medicine
Internal Medicine
medicine
Albuminuria
Humans
Diabetic Nephropathies
Epidermal Growth Factor
business.industry
Albumin
medicine.disease
Diabetes Mellitus, Type 1
medicine.anatomical_structure
Female
Microalbuminuria
business
Biomarkers
Glomerular Filtration Rate
Subjects
Details
- ISSN :
- 14645491 and 07423071
- Volume :
- 6
- Database :
- OpenAIRE
- Journal :
- Diabetic Medicine
- Accession number :
- edsair.doi.dedup.....952c32a46e3ff514f75e8a76f6084bbb