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Health-related quality of life in patients with primary sclerosing cholangitis
- Source :
- Liver International, 43(5), 1056-1067. Wiley-Blackwell, Liver International, 43(5), 1056-1067. Wiley, Liver international. Wiley-Blackwell, the EpiPSC2 Study Group 2023, ' Health-related quality of life in patients with primary sclerosing cholangitis : A longitudinal population-based cohort study ', Liver International, vol. 43, no. 5, pp. 1056-1067 . https://doi.org/10.1111/liv.15542
- Publication Year :
- 2023
-
Abstract
- Background & Aims: Data regarding health-related quality of life (HRQoL) in primary sclerosing cholangitis (PSC) are sparse and have only been studied cross-sectionally in a disease which runs a fluctuating and unpredictable course. We aim to describe HRQoL longitudinally by using repeated measurements in a population-based cohort. Methods: Every 3 months from May 2017 up to August 2020, patients received digital questionnaires at home. These included the EQ-5D, 5-D Itch, patient-based SCCAI and patient-based HBI. The SF-36, measuring HRQoL over eight dimensions as well as a physical component summary (PCS) and mental component summary (MCS) score, was sent annually. Data were compared with Dutch reference data and a matched IBD disease control from the population-based POBASIC cohort. Mixed-effects modelling was performed to identify factors associated with HRQoL. Results: Three hundred twenty-eight patients completed 2576 questionnaires. A significant reduction of small clinical relevance in several mean HRQoL scores was found compared with the Dutch reference population: 46.4 versus 48.0, p =.018 for PCS and 47.5 versus 50.5, p =.004 for MCS scores. HRQoL outcomes were significantly negatively associated with coexisting active IBD (PCS −12.2, p
Details
- Language :
- English
- ISSN :
- 14783223
- Database :
- OpenAIRE
- Journal :
- Liver international
- Accession number :
- edsair.doi.dedup.....9529e33260b17ec19bead7180698779f