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Concentrations of environmental phenols and parabens in milk, urine and serum of lactating North Carolina women
- Source :
- Reproductive Toxicology. 54:120-128
- Publication Year :
- 2015
- Publisher :
- Elsevier BV, 2015.
-
Abstract
- Phenols and parabens show some evidence for endocrine disruption in laboratory animals. The goal of the Methods Advancement for Milk Analysis (MAMA) Study was to develop or adapt methods to measure parabens (methyl, ethyl, butyl, propyl) and phenols (bisphenol A (BPA), 2,4- and 2,5-dichlorophenol, benzophenone-3, triclosan) in urine, milk and serum twice during lactation, to compare concentrations across matrices and with endogenous biomarkers among 34 North Carolina women. These non-persistent chemicals were detected in most urine samples (53-100%) and less frequently in milk or serum; concentrations differed by matrix. Although urinary parabens, triclosan and dichlorophenols concentrations correlated significantly at two time points, those of BPA and benzophenone-3 did not, suggesting considerable variability in those exposures. These pilot data suggest that nursing mothers are exposed to phenols and parabens; urine is the best measurement matrix; and correlations between chemical and endogenous immune-related biomarkers merit further investigation.
- Subjects :
- Serum
Adult
Bisphenol A
Breast milk
Adolescent
Urinary system
Parabens
Pilot Projects
Urine
Toxicology
Risk Assessment
Article
Paediatrics and Reproductive Medicine
Young Adult
chemistry.chemical_compound
Phenols
Risk Factors
Lactation
Biomonitoring
North Carolina
medicine
Humans
Food science
Milk, Human
Pharmacology and Pharmaceutical Sciences
BPA
Triclosan
Milk
medicine.anatomical_structure
chemistry
Maternal Exposure
Public Health and Health Services
Body Burden
Environmental Pollutants
Female
Parabens phenols
Biomarkers
Human
MAMA Study
Environmental Monitoring
Subjects
Details
- ISSN :
- 08906238
- Volume :
- 54
- Database :
- OpenAIRE
- Journal :
- Reproductive Toxicology
- Accession number :
- edsair.doi.dedup.....95218b5785fe6c049640826b9fe83664