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Lymphoid Tissue Mesenchymal Stromal Cells in Development and Tissue Remodeling
- Source :
- Stem Cells International, Vol 2016 (2016), Stem Cells International
- Publication Year :
- 2016
- Publisher :
- Hindawi Limited, 2016.
-
Abstract
- Secondary lymphoid organs (SLOs) are sites that facilitate cell-cell interactions required for generating adaptive immune responses. Nonhematopoietic mesenchymal stromal cells have been shown to play a critical role in SLO function, organization, and tissue homeostasis. The stromal microenvironment undergoes profound remodeling to support immune responses. However, chronic inflammatory conditions can promote uncontrolled stromal cell activation and aberrant tissue remodeling including fibrosis, thus leading to tissue damage. Despite recent advancements, the origin and role of mesenchymal stromal cells involved in SLO development and remodeling remain unclear.
- Subjects :
- 0301 basic medicine
lcsh:Internal medicine
Pathology
medicine.medical_specialty
Stromal cell
Mesenchymal stem cell
Review Article
Cell Biology
Biology
medicine.disease
Cell biology
03 medical and health sciences
030104 developmental biology
Tissue remodeling
Immune system
Lymphatic system
Fibrosis
medicine
lcsh:RC31-1245
Molecular Biology
Function (biology)
Tissue homeostasis
Subjects
Details
- ISSN :
- 16879678 and 1687966X
- Volume :
- 2016
- Database :
- OpenAIRE
- Journal :
- Stem Cells International
- Accession number :
- edsair.doi.dedup.....952044fbb222a22f378a3e03ee259f6b