Further studies on the effect of isoproterenol on amino acid transport into rat submandibular gland

Summary The effect of the administration of isoproterenol (IPR) on the uptake and steady state distribution of 14 C-amino-isobutyric acid ( 14 C-AIB) and 14 C-cycloleucine was measured in rats. Isoproterenol in small doses specifically enhanced the uptake of 14 C-AIB and 14 C-cycloleucine by the submandibular gland. In large doses the drug increased the uptake of the amino acid analogues also by the liver and diaphragmatic muscle. Removal of the superior cervical ganglion reduced the uptake of 14 C-AIB by the submandibular gland on the operated side. It is suggested that regulation of amino acid transport is one of the mechanisms by which IPR effects the growth of the submandibular gland.