Back to Search
Start Over
Microfluidic fabrication and characterization of Sorafenib-loaded lipid-polymer hybrid nanoparticles for controlled drug delivery
- Source :
- International Journal of Pharmaceutics. 581:119275
- Publication Year :
- 2020
- Publisher :
- Elsevier BV, 2020.
-
Abstract
- Lipid polymer hybrid nanoparticles (LPHNPs) have been merged as potential nanocarriers for treatment of cancer. In the present study, LPHNPs loaded with Sorafenib (SFN) were prepared with PLGA, Lecithin and DSPE-PEG 2000 by using the bulk nanoprecipitation and microfluidic (MF) co-flow nanoprecipitation techniques. Herein, a glass capillary microfluidic device was primed to optimize the LPHNPs and compared to the bulk nanoprecipitation method. The morphological analysis of prepared LPHNPs revealed the well-defined spherical nano-sized particles in bulk nanoprecipitation method. Whereas, core shell morphology was observed in the MF method. The formulation prepared by the MF method (MF1-MF3) indicated relatively higher % EE (95.0%, 93.8% and 88.7%) and controlled release of the SFN from the particles as compared to the LPHNPs obtained by the bulk nanoprecipitation method. However, the release of SFN from all LPHNP formulation followed Higuchi model (R2 = 0.9901–0.9389) with Fickian diffusion mechanism. Fourier transform infrared spectroscopy (FTIR), Differential scanning calorimetry (DSC) and powder X-rays diffraction (pXRD) studies depicted the compatibility of SFN with all the structural components. In addition, the colloidal stability, in vitro cytotoxicity and cell growth inhibition studies of LPHNPs also demonstrated stability in biological media, biocompatibility and safety with enhanced anti-proliferative effects than the free SFN in breast cancer and prostate cancer cells. In conclusion, LPHNPs provided a prospective platform for the cancer chemotherapy and substantially improved the knowledge of fabrication and optimization of the hybrid nanoparticles.
- Subjects :
- Materials science
Biocompatibility
Drug Compounding
Pharmaceutical Science
Nanoparticle
Antineoplastic Agents
02 engineering and technology
030226 pharmacology & pharmacy
Polyethylene Glycols
Chitosan
03 medical and health sciences
chemistry.chemical_compound
0302 clinical medicine
Differential scanning calorimetry
Polylactic Acid-Polyglycolic Acid Copolymer
Cell Line, Tumor
Neoplasms
Lecithins
Humans
Particle Size
Cell Proliferation
Drug Carriers
Phosphatidylethanolamines
Microfluidic Analytical Techniques
Sorafenib
021001 nanoscience & nanotechnology
Controlled release
Drug Liberation
PLGA
chemistry
Chemical engineering
Delayed-Action Preparations
Drug delivery
Nanoparticles
Drug Screening Assays, Antitumor
Nanocarriers
0210 nano-technology
Subjects
Details
- ISSN :
- 03785173
- Volume :
- 581
- Database :
- OpenAIRE
- Journal :
- International Journal of Pharmaceutics
- Accession number :
- edsair.doi.dedup.....95020ff2df441a996b830499747ae39e