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Infant gut microbiota and the hygiene hypothesis of allergic disease

Infant gut microbiota and the hygiene hypothesis of allergic disease

Authors :
David S. Guttman
Theodore Konya
Allan B. Becker
James A. Scott
Meghan B. Azad
Brenda Koster
Malcolm R. Sears
Heather Maughan
Radha Chari
Anita L. Kozyrskyj
Catherine J. Field
Source :
Allergy, Asthma, and Clinical Immunology : Official Journal of the Canadian Society of Allergy and Clinical Immunology
Publication Year :
2012
Publisher :
Springer Science and Business Media LLC, 2012.

Abstract

Background Inverse associations between allergic disease and having pets or siblings are commonly attributed to the hygiene hypothesis. As an extension, one could posit that a less diverse gut microbiome in the infant, also linked with the development of allergic disease, would be a function of fewer microbes in the home environment. Piglet studies, however, indicate that greater microbe diversity in the environment actually leads to reduced diversity of the gut microbiota. In this study, we characterize the infant gut microbiota in relation to environmental factors traditionally associated with the hygiene hypothesis.

Details

ISSN :
17101492
Volume :
8
Database :
OpenAIRE
Journal :
Allergy, Asthma & Clinical Immunology
Accession number :
edsair.doi.dedup.....94fae01faa4d4bffeeff49a26785e6a0
Full Text :
https://doi.org/10.1186/1710-1492-8-s1-a12