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Clonal karyotypic evolution in an embryonal rhabdomyosarcoma with trisomy 8 as the primary chromosomal abnormality
- Source :
- Genes, Chromosomes and Cancer. 7:240-244
- Publication Year :
- 1993
- Publisher :
- Wiley, 1993.
-
Abstract
- An embryonal rhabdomyosarcoma was analyzed cytogenetically. In primary cultures fed a serum-containing medium, 11 clones with karyotypic abnormalities were found. One had trisomy 8 only. The other 10 clones had trisomy 8 as well as additional evolutionary changes that included trisomy for part or all of chromosome 2, isochromosomes for the short and long arms of chromosome 11, isochromosomes for the long arm of chromosome 8, and extra copies of chromosome 8, some of which had an interstitial deletion in 8q. In those primary cultures that had grown in a chemically defined, serum-free medium and in all passaged cultures, trisomy 8 was the only aberration. Our findings and a survey of published information point to gain of one chromosome 8 as a frequent primary karyotypic abnormality in embryonal rhabdomyosarcomas. Trisomy for part or all of chromosomes 2 and 11 and additional gains of chromosome 8 material seem to be common secondary changes. © 1993 Wiley-Liss, Inc.
- Subjects :
- Male
Genetics
Cancer Research
Isochromosome
Karyotypic abnormality
Infant
Chromosome
Trisomy
Biology
Long arm
Trisomy 8
medicine.disease
Clone Cells
Abdominal Neoplasms
Karyotyping
Chromosomal Abnormality
medicine
Humans
Rhabdomyosarcoma, Embryonal
Embryonal rhabdomyosarcoma
Chromosomes, Human, Pair 8
Subjects
Details
- ISSN :
- 10982264 and 10452257
- Volume :
- 7
- Database :
- OpenAIRE
- Journal :
- Genes, Chromosomes and Cancer
- Accession number :
- edsair.doi.dedup.....94ce675f87cd4a613ef550ffd96e3b9f