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Association Study Between White Matter Microstructure and Intelligence Decline in Schizophrenia

Authors :
Junya Matsumoto
Kenichiro Miura
Masaki Fukunaga
Kiyotaka Nemoto
Daisuke Koshiyama
Naohiro Okada
Kentaro Morita
Hidenaga Yamamori
Yuka Yasuda
Michiko Fujimoto
Satsuki Ito
Naomi Hasegawa
Yoshiyuki Watanabe
Kiyoto Kasai
Ryota Hashimoto
Source :
Clinical EEG and Neuroscience. :155005942110633
Publication Year :
2021
Publisher :
SAGE Publications, 2021.

Abstract

Patients with schizophrenia can exhibit intelligence decline, which is an important element of cognitive impairment. Previous magnetic resonance imaging (MRI) studies have demonstrated that patients with schizophrenia have altered gray matter structures and functional connectivity associated with intelligence decline defined by a difference between premorbid and current intelligence quotients (IQs). However, it has remained unclear whether white matter microstructures are related to intelligence decline. In the present study, the indices of diffusion tensor imaging (DTI) obtained from 138 patients with schizophrenia and 554 healthy controls were analyzed. The patients were classified into three subgroups based on intelligence decline: deteriorated (94 patients), preserved (42 patients), and compromised IQ (2 patients) groups. Given that the DTI of each subject was acquired using either one of two different MRI scanners, we analyzed DTI indices separately for each scanner group. In the comparison between the deteriorated IQ group and the healthy controls, differences in some DTI indices were noted in three regions of interest irrespective of the MRI scanners, whereas differences in only one region of interest were noted between the preserved IQ group and the healthy controls. However, the comparisons between the deteriorated and preserved IQ groups did not show any reproducible differences. Together with the previous findings, it is thought that gray matter structures and functional connectivity are more promising as markers of intelligence decline in schizophrenia than white matter microstructures.

Details

ISSN :
21695202 and 15500594
Database :
OpenAIRE
Journal :
Clinical EEG and Neuroscience
Accession number :
edsair.doi.dedup.....94cb7289d71956aec7b536fef8b61ef6