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The Incidence of Cancer in a PopulationāBased Cohort of Canadian Heart Transplant Recipients
- Source :
- American Journal of Transplantation. 10:637-645
- Publication Year :
- 2010
- Publisher :
- Elsevier BV, 2010.
-
Abstract
- To assess the long-term risk of developing cancer among heart transplant recipients compared to the Canadian general population, we carried out a retrospective cohort study of 1703 patients who received a heart transplant between 1981 and 1998, identified from the Canadian Organ Replacement Register database. Vital status and cancer incidence were determined through record linkage to the Canadian Mortality Database and Canadian Cancer Registry. Cancer incidence rates among heart transplant patients were compared to those of the general population. The observed number of incident cancers was 160 with 58.9 expected in the general population (SIR = 2.7, 95% CI = 2.3, 3.2). The highest ratios were for non-Hodgkin's lymphoma (NHL) (SIR = 22.7, 95% CI = 17.3, 29.3), oral cancer (SIR = 4.3, 95% CI = 2.1, 8.0) and lung cancer (SIR = 2.0, 95% CI = 1.2, 3.0). Compared to the general population, SIRs for NHL were particularly elevated in the first year posttransplant during more recent calendar periods, and among younger patients. Within the heart transplant cohort, overall cancer risks increased with age, and the 15-year cumulative incidence of all cancers was estimated to be 17%. There is an excess of incident cases of cancer among heart transplant recipients. The relative excesses are most marked for NHL, oral and lung cancer.
- Subjects :
- Adult
Male
Risk
Canada
medicine.medical_specialty
Adolescent
Heart Diseases
medicine.medical_treatment
Population
Cohort Studies
Neoplasms
Internal medicine
medicine
Humans
Immunology and Allergy
Pharmacology (medical)
Cumulative incidence
Child
education
Heart transplantation
Transplantation
education.field_of_study
business.industry
Incidence
Lymphoma, Non-Hodgkin
Cancer
Retrospective cohort study
Middle Aged
medicine.disease
Surgery
Cancer registry
Treatment Outcome
Cohort
Heart Transplantation
Female
Mouth Neoplasms
business
Cohort study
Subjects
Details
- ISSN :
- 16006135
- Volume :
- 10
- Database :
- OpenAIRE
- Journal :
- American Journal of Transplantation
- Accession number :
- edsair.doi.dedup.....94ca4a29264887eced6912e45022c569