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Myonuclear content regulates cell size with similar scaling properties in mice and humans
- Source :
- Nature Communications, Nature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
- Publication Year :
- 2020
- Publisher :
- Nature Publishing Group UK, 2020.
-
Abstract
- Muscle fibers are the largest cells in the body, and one of its few syncytia. Individual cell sizes are variable and adaptable, but what governs cell size has been unclear. We find that muscle fibers are DNA scarce compared to other cells, and that the nuclear number (N) adheres to the relationship N = aVb where V is the cytoplasmic volume. N invariably scales sublinearly to V (b<br />Muscle fibers are the largest cells in the body and contain less DNA per unit volume than other cells even if they have multiple nuclei. Here, the authors show that the number of nuclei regulates the cell size with similar scaling properties in mice and humans.
- Subjects :
- 0301 basic medicine
Adult
Male
Cytoplasm
Intravital Microscopy
Multiple nuclei model
Science
Biopsy
Cell
Muscle Fibers, Skeletal
General Physics and Astronomy
Skeletal muscle
General Biochemistry, Genetics and Molecular Biology
Article
Cell size
03 medical and health sciences
chemistry.chemical_compound
Mice
Young Adult
0302 clinical medicine
Developmental biology
medicine
Myocyte
Animals
Humans
Muscle, Skeletal
Scaling
Cell Size
Cell Nucleus
Syncytium
Multidisciplinary
Microscopy, Confocal
Chemistry
General Chemistry
DNA
Healthy Volunteers
Cell biology
030104 developmental biology
medicine.anatomical_structure
Female
Single-Cell Analysis
030217 neurology & neurosurgery
Subjects
Details
- Language :
- English
- ISSN :
- 20411723
- Volume :
- 11
- Database :
- OpenAIRE
- Journal :
- Nature Communications
- Accession number :
- edsair.doi.dedup.....94c03d04bc2c283536e308e30d8d5864