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Na+ mechanism of δ-opioid receptor induced protection from anoxic K+ leakage in the cortex
- Source :
- Cellular and Molecular Life Sciences. 66:1105-1115
- Publication Year :
- 2009
- Publisher :
- Springer Science and Business Media LLC, 2009.
-
Abstract
- Activation of delta-opioid receptors (DOR) attenuates anoxic K(+) leakage and protects cortical neurons from anoxic insults by inhibiting Na(+) influx. It is unknown, however, which pathway(s) that mediates the Na(+) influx is the target of DOR signal. In the present work, we found that, in the cortex, (1) DOR protection was largely dependent on the inhibition of anoxic Na(+) influxes mediated by voltage-gated Na(+) channels; (2) DOR activation inhibited Na(+) influx mediated by ionotropic glutamate N-methyl-D-aspartate (NMDA) receptors, but not that by non-NMDA receptors, although both played a role in anoxic K(+) derangement; and (3) DOR activation had little effect on Na(+)/Ca(2+) exchanger-based response to anoxia. We conclude that DOR activation attenuates anoxic K(+) derangement by restricting Na(+) influx mediated by Na(+) channels and NMDA receptors, and that non-NMDA receptors and Na(+)/Ca(2+) exchangers, although involved in anoxic K(+) derangement in certain degrees, are less likely the targets of DOR signal.
- Subjects :
- Male
medicine.drug_class
In Vitro Techniques
Receptors, N-Methyl-D-Aspartate
Sodium Channels
Sodium-Calcium Exchanger
Article
δ-opioid receptor
Mice
Cellular and Molecular Neuroscience
Opioid receptor
Receptors, Opioid, delta
medicine
Animals
Hypoxia, Brain
Receptor
Molecular Biology
Cerebral Cortex
Neurons
Pharmacology
Sodium-calcium exchanger
Chemistry
Sodium channel
Sodium
Glutamate receptor
Cell Biology
Cations, Monovalent
Mice, Inbred C57BL
Biochemistry
Potassium
Biophysics
Molecular Medicine
NMDA receptor
Ion Channel Gating
Ionotropic effect
Subjects
Details
- ISSN :
- 14209071 and 1420682X
- Volume :
- 66
- Database :
- OpenAIRE
- Journal :
- Cellular and Molecular Life Sciences
- Accession number :
- edsair.doi.dedup.....94b738f5ac50c63b5609df7f076c68b7