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Evaluation of superoxide dismutase from Helicobacter pylori as a protective vaccine antigen
- Source :
- Vaccine. 29:1514-1518
- Publication Year :
- 2011
- Publisher :
- Elsevier BV, 2011.
-
Abstract
- Helicobacter pylori, the major cause of gastric cancer, have mechanisms that allow colonization of the inhospitable gastric mucosa, including enzymes such as superoxide dismutase (SOD) which protect against reactive oxygen species. As SOD is essential for in vivo colonization, we theorized it might constitute a viable vaccine target. H. pylori SOD was expressed in E. coli and a purified recombinant protein used to vaccinate mice, prior to live H. pylori challenge. Partial protective immunity was induced, similar to that commonly observed with other antigens tested previously. This suggests SOD may have utility in a combination vaccine comprising several protective antigens.
- Subjects :
- Helicobacter Infections
Microbiology
Superoxide dismutase
Mice
03 medical and health sciences
Antigen
Immunity
Escherichia coli
Gastric mucosa
medicine
Animals
030304 developmental biology
chemistry.chemical_classification
Antigens, Bacterial
0303 health sciences
Reactive oxygen species
Helicobacter pylori
General Veterinary
General Immunology and Microbiology
biology
Superoxide Dismutase
030306 microbiology
Public Health, Environmental and Occupational Health
biology.organism_classification
Antibodies, Bacterial
Recombinant Proteins
Immunity, Humoral
3. Good health
Mice, Inbred C57BL
Bacterial vaccine
Infectious Diseases
medicine.anatomical_structure
chemistry
Bacterial Vaccines
Immunology
biology.protein
Molecular Medicine
Female
Antibody
Subjects
Details
- ISSN :
- 0264410X
- Volume :
- 29
- Database :
- OpenAIRE
- Journal :
- Vaccine
- Accession number :
- edsair.doi.dedup.....94b17f05b25e2cc48be91b88f06d050a