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The effects of general anaesthesia on the asphyxiated foetal lamb in utero
- Source :
- Canadian Anaesthetists’ Society Journal. 32:577-582
- Publication Year :
- 1985
- Publisher :
- Springer Science and Business Media LLC, 1985.
-
Abstract
- The effects of anaesthetic agents, per se, on the asphyxiated foetus are difficult to quantitate clinically. Anaesthesia is often necessary in foetal distress, however, to effect a rapid delivery. To investigate the effect of general anaesthetic agents commonly used for Caesarean section we administered these agents to 18 chronically prepared pregnant ewes with asphyxiated foetuses in utero. The foetuses were asphyxiated by partial occlusion of the umbilical cord until foetal arterial pH had decreased from 7.30 to a range of 7.08-7.13. The animals were divided into three groups: Group A which received no anaesthesia and thus served as a control, Group B which received thiopentone (3 mg . kg-1) intravenously followed by 50 per cent nitrous oxide and 0.5 per cent halothane in oxygen for 15 minutes, and Group C which received thiopentone (3 mg . kg-1) followed by one per cent halothane in oxygen for 15 minutes. Foetal cerebral, myocardial, and renal blood flows were measured by injection of radioactive microspheres after production of asphyxia and after 5 and 15 minutes of anaesthesia. General anaesthesia in both groups B and C abolished the hypertension and bradycardia produced by foetal asphyxia secondary to umbilical cord occlusion. There were no significant differences between Groups B and C in foetal pH, PCO2, or PO2. Two foetuses in the nitrous oxide group died after ten minutes of anesthesia, but the aetiology of the sudden demise is unclear. We conclude that general anaesthesia abolishes the foetal response to umbilical cord occlusion and does not improve foetal oxygenation or acid-base status.
- Subjects :
- medicine.medical_specialty
Time Factors
medicine.medical_treatment
Nitrous Oxide
Anesthesia, General
Umbilical cord
Renal Circulation
Asphyxia
Fetal Heart
Fetus
Heart Rate
Pregnancy
medicine
Animals
Caesarean section
General anaesthesia
Umbilical Cord Occlusion
Thiopental
reproductive and urinary physiology
Sheep
Cesarean Section
business.industry
General Medicine
Surgery
Oxygen
Fetal Diseases
Anesthesiology and Pain Medicine
medicine.anatomical_structure
In utero
Anesthesia
embryonic structures
Female
medicine.symptom
Halothane
business
medicine.drug
Subjects
Details
- ISSN :
- 14968975 and 00082856
- Volume :
- 32
- Database :
- OpenAIRE
- Journal :
- Canadian Anaesthetists’ Society Journal
- Accession number :
- edsair.doi.dedup.....94ad5ce24ed7e6c82dfb98ab426e0b17