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Differential Effect of Retroactive Interference on Object and Spatial Memory in the Course of Healthy Aging and Neurodegeneration
- Source :
- Frontiers in Aging Neuroscience, Frontiers in aging neuroscience 10, 333 (2018). doi:10.3389/fnagi.2018.00333, Frontiers in Aging Neuroscience, Vol 10 (2018)
- Publication Year :
- 2018
- Publisher :
- Frontiers Media SA, 2018.
-
Abstract
- Objective: In subjects with mild cognitive impairment (MCI), interference during memory consolidation may further degrade subsequent recall of newly learned information. We investigated whether spatial and object memory are differentially susceptible to interference. Method: Thirty-nine healthy young subjects, 39 healthy older subjects, and 12 subjects suffering from MCI encoded objects and their spatial position on a 4-by-5 grid. Encoding was followed by either: (i) a pause; (ii) an interference task immediately following encoding; or (iii) an interference task following encoding after a 6-min delay. Type of interference (no, early, delayed) was applied in different sessions and order was counterbalanced. Twelve minutes after encoding, subjects saw objects previously presented or new ones. Subjects indicated whether they recognized the object, and if so, the objects’ position during encoding. Results: Interference during consolidation provoked a negative effect on spatial memory in young more than older controls. In MCI, object but not spatial memory was affected by interference. Furthermore, a shift from fine- to coarse-grained spatial representation was observed in MCI. No differential effect of early vs. late interference (EI vs. LI) in either of the groups was detected. Conclusions: Data show that consolidation in healthy aging and MCI differs from consolidation in young controls. Data suggest differential processes underlying object and spatial memory and that these are differentially affected by aging and MCI.
- Subjects :
- Aging
medicine.medical_specialty
hippocampus
Cognitive Neuroscience
Interference theory
recall
Amnesia
Hippocampus
Audiology
Interference (genetic)
050105 experimental psychology
lcsh:RC321-571
03 medical and health sciences
0302 clinical medicine
amnesia
Encoding (memory)
medicine
0501 psychology and cognitive sciences
ddc:610
lcsh:Neurosciences. Biological psychiatry. Neuropsychiatry
Original Research
Recall
05 social sciences
Object (computer science)
Memory consolidation
recognition
medicine.symptom
Psychology
consolidation
030217 neurology & neurosurgery
Neuroscience
Subjects
Details
- ISSN :
- 16634365
- Volume :
- 10
- Database :
- OpenAIRE
- Journal :
- Frontiers in Aging Neuroscience
- Accession number :
- edsair.doi.dedup.....94ab1916198a60aa5385f3d563f084a7