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Tissue Responses to Endovascular Stent Grafts for Saccular Abdominal Aortic Aneurysms in a Canine Model
- Source :
- Journal of Korean Medical Science
- Publication Year :
- 2012
- Publisher :
- The Korean Academy of Medical Sciences, 2012.
-
Abstract
- We investigated tissue responses to endoskeleton stent grafts for saccular abdominal aortic aneurysms (AAAs) in canines. Saccular AAAs were made with Dacron patch in 8 dogs, and were excluded by endoskeleton stent grafts composed of nitinol stent and expanded polytetrafluoroethylene graft. Animals were sacrificed at 2 months (Group 1; n = 3) or 6 months (Group 2; n = 5) after the placement, respectively. The aortas embedding stent grafts were excised en bloc for gross inspection and sliced at 5 to 8 mm intervals for histopathologic evaluation. Stent grafts were patent in all except a dog showing a thrombotic occlusion in Group 2. In the 7 dogs with patent lumen, the graft overhanging the saccular aneurysm was covered by thick or thin thrombi with no endothelial layer, and the graft over the aortic wall was completely covered by neointima with an endothelial layer. Transgraft cell migration was less active at an aneurysm than at adjacent normal aorta. In conclusion, endoskeleton stent grafts over saccular aneurysms show no endothelial coverage and poor transgraft cell migration in a canine model.
- Subjects :
- Neointima
medicine.medical_specialty
medicine.medical_treatment
Cardiovascular Disorders
Endothelial cells
Lumen (anatomy)
Prostheses
Aortic aneurysm
Endoskeleton
Aneurysm
Dogs
Cell Movement
medicine.artery
medicine
Alloys
Animals
cardiovascular diseases
Polytetrafluoroethylene
Aorta
Ultrasonography
medicine.diagnostic_test
business.industry
Angiography
Stent
Thrombosis
General Medicine
medicine.disease
equipment and supplies
Surgery
Disease Models, Animal
surgical procedures, operative
cardiovascular system
Original Article
Stents
business
Tomography, X-Ray Computed
Aortic Aneurysm, Abdominal
Subjects
Details
- Language :
- English
- ISSN :
- 15986357 and 10118934
- Volume :
- 27
- Issue :
- 10
- Database :
- OpenAIRE
- Journal :
- Journal of Korean Medical Science
- Accession number :
- edsair.doi.dedup.....94a6af7e1535eb188bea8dd0cc999a25