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Atlas of RNA sequencing profiles for normal human tissues
- Source :
- Scientific Data, Vol 6, Iss 1, Pp 1-9 (2019), Scientific Data
- Publication Year :
- 2019
- Publisher :
- Springer Science and Business Media LLC, 2019.
-
Abstract
- Comprehensive analysis of molecular pathology requires a collection of reference samples representing normal tissues from healthy donors. For the available limited collections of normal tissues from postmortal donors, there is a problem of data incompatibility, as different datasets generated using different experimental platforms often cannot be merged in a single panel. Here, we constructed and deposited the gene expression database of normal human tissues based on uniformly screened original sequencing data. In total, 142 solid tissue samples representing 20 organs were taken from post-mortal human healthy donors of different age killed in road accidents no later than 36 hours after death. Blood samples were taken from 17 healthy volunteers. We then compared them with the 758 transcriptomic profiles taken from the other databases. We found that overall 463 biosamples showed tissue-specific rather than platform- or database-specific clustering and could be aggregated in a single database termed Oncobox Atlas of Normal Tissue Expression (ANTE). Our data will be useful to all those working with the analysis of human gene expression.<br />Design Type(s)gene expression analysis objective • data integration objective • organism part comparison design • transcription profiling designMeasurement Type(s)transcription profiling assayTechnology Type(s)RNA sequencingFactor Type(s)sex • age • organism subdivisionSample Characteristic(s)Homo sapiens • kidney • Kidney • Colon • Liver • brain • Lung • endometrium • Ovary • prostate gland • Esophagus • Stomach • Mammary gland • Thyroid gland • Pancreas • Tonsil • skeletal muscle tissue • small intestine • Adrenal gland • urinary bladder • skin of body • uterus • uterine cervix • Small intestine • tonsil • blood • bone marrow • esophagus • liver Machine-accessible metadata file describing the reported data (ISA-Tab format)
- Subjects :
- Statistics and Probability
Data Descriptor
010504 meteorology & atmospheric sciences
Sequence analysis
Sequencing data
Normal tissue
Computational biology
Biology
Library and Information Sciences
01 natural sciences
Education
03 medical and health sciences
Gene expression analysis
stomatognathic system
Genetics research
Databases, Genetic
Healthy volunteers
Humans
lcsh:Science
030304 developmental biology
0105 earth and related environmental sciences
0303 health sciences
Sequence Analysis, RNA
Molecular pathology
Gene Expression Profiling
RNA
RNA sequencing
Computer Science Applications
Gene expression profiling
Gene expression database
Organ Specificity
lcsh:Q
Statistics, Probability and Uncertainty
Genetic databases
Transcriptome
Information Systems
Subjects
Details
- Language :
- English
- ISSN :
- 20524463
- Volume :
- 6
- Database :
- OpenAIRE
- Journal :
- Scientific Data
- Accession number :
- edsair.doi.dedup.....94a28218a11bbc9070937069f41552b5
- Full Text :
- https://doi.org/10.1038/s41597-019-0043-4