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Evolution of Plasmodium falciparum antimalarial drug resistance markers post-adoption of artemisinin-based combination therapies in Yaounde, Cameroon
- Source :
- Niba, P T N, Nji, A M, Chedjou, J P K, Hansson, H, Hocke, E F, Ali, I M, Achonduh-Atijegbe, O, Evehe, M S B, Jørgensen, M H M, Fomboh, C T, Cui, L, Stresman, G, Bigoga, J D, Alifrangis, M & Mbacham, W F 2023, ' Evolution of Plasmodium falciparum antimalarial drug resistance markers post-adoption of artemisinin-based combination therapies in Yaounde, Cameroon ', International Journal of Infectious Diseases, vol. 132, pp. 108-117 . https://doi.org/10.1016/j.ijid.2023.03.050
- Publication Year :
- 2023
- Publisher :
- Elsevier BV, 2023.
-
Abstract
- Objectives: This study aimed to investigate the evolution of Plasmodium falciparum antimalarial drug resistance markers by comparing the pre- and post-adoption of artemisinin-based combination therapies (ACTs) in Yaounde, Cameroon. Methods: The molecular characterization of known antimalarial drug resistance markers (Pfcrt, Pfmdr1, Pfdhfr, Pfdhps, and Pfk13) in P. falciparum-positive samples collected in 2014 and 2019-2020 was achieved using nested polymerase chain reaction, followed by targeted amplicon deep sequencing on the Illumina MiSeq platform. Data derived were compared with those published during the pre-ACT adoption period from 2004 to 2006. Results: A high prevalence of Pfmdr1 184F, Pfdhfr 51I/59R/108N, and Pfdhps 437G mutant alleles was observed during the post-ACT adoption period. The Pfcrt 76T and Pfmdr1 86Y mutant alleles significantly declined between 2004 and 2020 (P
Details
- ISSN :
- 12019712
- Volume :
- 132
- Database :
- OpenAIRE
- Journal :
- International Journal of Infectious Diseases
- Accession number :
- edsair.doi.dedup.....94a01f9aefcaca3b6939ca5ad3433924
- Full Text :
- https://doi.org/10.1016/j.ijid.2023.03.050