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Definition of a mouse microglial subset that regulates neuronal development and proinflammatory responses in the brain

Authors :
Xianli Shen
Yiguo Qiu
Andrew E. Wight
Hye-Jung Kim
Harvey Cantor
Source :
Proceedings of the National Academy of Sciences of the United States of America. 119(8)
Publication Year :
2021

Abstract

SignificanceCD11c+microglia enriched for osteopontin (OPN) expression appear at distinct stages of brain development, aging, and several neurodegenerative disorders. Whether coexpression of CD11c and OPN results from microglial activation or represents a part of a subset-specific genetic program is unknown. We find that this CD11c+microglial subset is formed before birth upon uptake of apoptotic neurons. Our analysis also suggests that it represents a stable subset that requires OPN to mediate engulfment of synaptic proteins, proliferate, and develop a proinflammatory phenotype. Definition of OPN-producing CD11c+microglia as a specialized microglial subset provides insight into the contribution of microglial differentiation to brain development and function in health and disease.

Details

ISSN :
10916490
Volume :
119
Issue :
8
Database :
OpenAIRE
Journal :
Proceedings of the National Academy of Sciences of the United States of America
Accession number :
edsair.doi.dedup.....9487edc155f14894808d8e6adf24a73a