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Definition of a mouse microglial subset that regulates neuronal development and proinflammatory responses in the brain
- Source :
- Proceedings of the National Academy of Sciences of the United States of America. 119(8)
- Publication Year :
- 2021
-
Abstract
- SignificanceCD11c+microglia enriched for osteopontin (OPN) expression appear at distinct stages of brain development, aging, and several neurodegenerative disorders. Whether coexpression of CD11c and OPN results from microglial activation or represents a part of a subset-specific genetic program is unknown. We find that this CD11c+microglial subset is formed before birth upon uptake of apoptotic neurons. Our analysis also suggests that it represents a stable subset that requires OPN to mediate engulfment of synaptic proteins, proliferate, and develop a proinflammatory phenotype. Definition of OPN-producing CD11c+microglia as a specialized microglial subset provides insight into the contribution of microglial differentiation to brain development and function in health and disease.
Details
- ISSN :
- 10916490
- Volume :
- 119
- Issue :
- 8
- Database :
- OpenAIRE
- Journal :
- Proceedings of the National Academy of Sciences of the United States of America
- Accession number :
- edsair.doi.dedup.....9487edc155f14894808d8e6adf24a73a