Back to Search
Start Over
Role of hnRNP-A1 and miR-590-3p in neuronal death: genetics and expression analysis in patients with Alzheimer disease and frontotemporal lobar degeneration
- Publication Year :
- 2011
-
Abstract
- An association study of heterogeneous nuclear ribonucleoprotein (hnRNP)-A1 was carried out in a population of 274 patients with frontotemporal lobar degeneration (FTLD) and 287 with Alzheimer disease (AD) as compared with 344 age-and gender-matched controls. In addition, we evaluated expression levels of hnRNP-A1 and its regulatory microRNA (miR)-590-3p in blood cells from patients and controls. A statistically significant increased frequency of the hnRNP-A1 rs7967622 C/C genotype was observed in FTLD, but not in AD, in patients as compared to controls (23.0 versus 15.4%; p = 0.022, odds ratio [OR] 1.64, confidence interval [CI] 1.09-2.46). Stratifying according to gender, a statistically significant increased frequency of the hnRNP-A1 rs7967622 C/C genotype was observed in male patients as compared to male controls (23.1 versus 11.3%; p = 0.015, OR 2.36, CI 1.22-4.58 but not in females. Considering the rs4016671 single-nucleotide polymorphism (SNP), all patients and controls were wild type. Significantly increased hnRNP-A1 relative expression levels in peripheral blood mononuclear cells (PBMCs) was observed in patients with AD, but not with FTLD, as compared to controls (2.724 ± 0.570 versus 1.076 ± 0.187, p = 0.021). Decreased relative expression levels of hsa-miR-590-3p was observed in patients with AD versus controls (0.685 ± 0.080 versus 0.931 ± 0.111, p = 0.079), and correlated negatively with hnRNP-A1 mRNA levels (r =-0.615, p = 0.0237). According to these findings, hnRNP-A1 and its transcription regulatory factor miR-590-3p are disregulated in patients with AD, and the hnRNP-A1 rs7967622 C/C genotype is likely a risk factor for FTLD in male populations. © 2011, Mary Ann Liebert, Inc.
- Subjects :
- Male
Aging
Programmed cell death
Pathology
medicine.medical_specialty
Heterogeneous nuclear ribonucleoprotein
Heterogeneous Nuclear Ribonucleoprotein A1
Molecular Sequence Data
Population
Polymorphism, Single Nucleotide
environment and public health
FTD
Alzheimer's disease
hnRNP-A1
miR-590-3p
neuronal death
Gene Frequency
Alzheimer Disease
Heterogeneous-Nuclear Ribonucleoprotein Group A-B
mental disorders
microRNA
Humans
Medicine
education
Allele frequency
Alleles
Aged
Neurons
Regulation of gene expression
education.field_of_study
Base Sequence
Cell Death
miRNAs, Alzheimer's disease, frontotemporal lobar degeneration
business.industry
Frontotemporal lobar degeneration
medicine.disease
nervous system diseases
MicroRNAs
Gene Expression Regulation
Case-Control Studies
Settore MED/26 - Neurologia
Female
Frontotemporal Lobar Degeneration
Geriatrics and Gerontology
business
Sequence Alignment
Subjects
Details
- Language :
- English
- Database :
- OpenAIRE
- Accession number :
- edsair.doi.dedup.....94871f75693c5a3430e8ae90cec456e3