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No association of proton pump inhibitor use with fasting or postload glycaemia in patients with cardiovascular disease : a cross-sectional retrospective study
- Source :
- International Journal of Medical Sciences
- Publication Year :
- 2017
-
Abstract
- Background: Proton pump inhibitor (PPI) use was reportedly associated with an excess of adverse cardiovascular (CV) events, thus making their systemic effects relevant to public health. PPIs reduce gastric acid secretion, causing increased gastrin release. Gastrin stimulates β-cell neogenesis and enhances insulin release, exerting an incretin-like effect. Our aim was to assess, if PPI usage is associated with altered glycaemia in patients with CV disease. Methods: We retrospectively analyzed medical records of 102 subjects (80 with ischemic heart disease) who underwent a routine oral glucose tolerance test while hospitalized in a cardiology department. Fasting and 2-h postload glucose levels were compared according to PPI use for ≥1 month prior to admission. Results: Compared to 51 subjects without PPIs, those on a PPI were older, more frequently male, had a lower body-mass index and a tendency to a worse renal function. PPI users and non-users exhibited similar glucose levels at baseline (5.6 ± 0.9 vs. 5.5 ± 1.1 mmol/l, P = 0.5) and 2-hrs post glucose intake (9.8 ± 3.0 vs. 9.9 ± 3.4 mmol/l, P = 0.9). This was consistent across subgroups stratified by gender or diabetes status. The results were substantially unchanged after adjustment for different characteristics of subjects with and without PPIs. Conclusions: PPI use does not appear associated with altered glycaemia in subjects with CV disease. Unchanged glucose tolerance despite PPI usage may result from simultaneous activation of pathways that counteract the putative PPI-induced incretin-like effect.
- Subjects :
- Blood Glucose
Male
medicine.medical_specialty
medicine.drug_class
glucose tolerance
Gastrointestinal Diseases
medicine.medical_treatment
Proton-pump inhibitor
Renal function
030209 endocrinology & metabolism
Disease
030204 cardiovascular system & hematology
proton pump inhibitors
Incretins
Neogenesis
Glucagon-Like Peptide-1 Receptor
03 medical and health sciences
0302 clinical medicine
cardiovascular disease
Glucagon-Like Peptide 1
Internal medicine
Gastrins
medicine
Humans
Gastrin
Aged
Retrospective Studies
biology
business.industry
Insulin
Retrospective cohort study
Proton Pump Inhibitors
General Medicine
Fasting
Glucose Tolerance Test
Middle Aged
biology.organism_classification
Endocrinology
Cross-Sectional Studies
Diabetes Mellitus, Type 2
Cardiovascular Diseases
Gastric acid
Female
business
Research Paper
Subjects
Details
- Language :
- English
- Database :
- OpenAIRE
- Journal :
- International Journal of Medical Sciences
- Accession number :
- edsair.doi.dedup.....947c28b60a4a0383c3a27d29e3d3878b