Influence of Nonspecific Interactions on Protein Associations: Implications for Biochemistry In Vivo

31 p.-7 fig.
The cellular interior is composed of a variety of microenvironments defined by distinct local compositions and composition-dependent intermolecular interactions.We review the various types of nonspecific interactions between proteins and between proteins and other macromolecules and supramolec ular structures that influence the state of association and functional prop erties of a given protein existing within a particular microenvironment at a particular point in time. The present state of knowledge is summarized, and suggestions for fruitful directions of research are offered.
G.R.’s research is supported by Spanish Government Grant PID2019-104544GB-I00. A.P.M.’s research is supported by the Intramural Research Program, National Institute of Diabetes and Digestive and Kidney Diseases, NIH.