Back to Search
Start Over
Flow-Mediated Vasodilation and Carotid Intima-Media Thickness in Systemic Sclerosis
- Source :
- Annals of the New York Academy of Sciences. 1108:283-290
- Publication Year :
- 2007
- Publisher :
- Wiley, 2007.
-
Abstract
- Increased evidence suggests an accelerated macrovascular disease in systemic sclerosis (SSc). Brachial artery flow-mediated vasodilation (FMD) and carotid intima-media thickness (IMT) are two indicators of subclinic cardiovascular disease and are frequently used as surrogate measures of subclinic atherosclerosis. The aim of this study was to evaluate macrovascular involvement in SSc. We studied 35 SSc patients (6 males and 29 females; 11 with diffuse and 24 with limited disease) and 20 healthy controls. Brachial artery FMD was assessed by method described by Celermajer in all patients and 13 control subjects. IMT was measured using high-resolution B-mode ultrasonography in patients and controls. Traditional risk factors for atherosclerosis (hypertension, dyslipidemia, and smoke) were also assessed. FMD was significantly impaired (3.41% +/- 4.56% versus 7.66% +/- 4.24%; P < 0.037) and IMT was significantly elevated compared with healthy controls (0.93 +/- 0.29 mm versus 0.77 +/- 0.13 mm; P < 0.005). FMD was not significantly different in SSc with increased IMT compared with those with normal IMT). No correlation was found between risk factors for atherosclerosis and the impairment of FMD or IMT in SSc patients. The impairment of endothelial function and structural changes of large vessels are evident in SSc, but do not seem associated with traditional risk factors for atherosclerosis. Prospective studies including also clinical outcomes are needed to assess the features and significance of macrovacular involvement in SSc.
- Subjects :
- Male
medicine.medical_specialty
Brachial Artery
Vasodilation
Disease
General Biochemistry, Genetics and Molecular Biology
History and Philosophy of Science
medicine.artery
Internal medicine
medicine
Humans
Vascular Diseases
cardiovascular diseases
Brachial artery
Prospective cohort study
Ultrasonography
Macrovascular disease
Scleroderma, Systemic
business.industry
General Neuroscience
Middle Aged
medicine.disease
Carotid Arteries
Endocrinology
Intima-media thickness
cardiovascular system
Cardiology
Female
Tunica Intima
Tunica Media
business
Dyslipidemia
Flow-Mediated Vasodilation
Subjects
Details
- ISSN :
- 00778923
- Volume :
- 1108
- Database :
- OpenAIRE
- Journal :
- Annals of the New York Academy of Sciences
- Accession number :
- edsair.doi.dedup.....946f06080113a022393b604c435767b8