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Monozygotic dichorionic twins heterokaryotypic for duplication chromosome 2q13-q23.3
- Source :
- Fetal diagnosis and therapy. 25(4)
- Publication Year :
- 2008
-
Abstract
- We present an evaluation of the diagnosis, management and outcome of a pair of heterokaryotypic monozygotic dichorionic twins. The heterokaryotype was an incidental finding from an amniocentesis performed for prenatal diagnosis of β-thalassaemia major in a pair of dichorionic twins. Monozygocity was revealed by QF-PCR showing identical short tandem repeat markers on chromosomes 21, 18, 13, X and Y. The twins were heterokaryotypic for duplication chromosome 2q13-q23.3, as shown by array comparative genomic hybridization. Selective foeticide was performed. This case demonstrates that heterokaryotypic monozygotic dichorionic twins are a genetic possibility that does occur.
- Subjects :
- Adult
Embryology
Monozygotic twin
Genetic Counseling
Gestational Age
Biology
Polymerase Chain Reaction
Chromosome (genetic algorithm)
Pregnancy
Gene Duplication
Prenatal Diagnosis
Gene duplication
medicine
Humans
Radiology, Nuclear Medicine and imaging
Genetic Testing
Genetics
Comparative Genomic Hybridization
Incidental Findings
medicine.diagnostic_test
beta-Thalassemia
Obstetrics and Gynecology
General Medicine
Twins, Monozygotic
Pregnancy Reduction, Multifetal
Dichorionic twins
Chromosomes, Human, Pair 2
Karyotyping
Pediatrics, Perinatology and Child Health
Amniocentesis
Female
Subjects
Details
- ISSN :
- 14219964
- Volume :
- 25
- Issue :
- 4
- Database :
- OpenAIRE
- Journal :
- Fetal diagnosis and therapy
- Accession number :
- edsair.doi.dedup.....946e1c01c5bcdb687039f4acd1eb744b